445
Participants
Start Date
January 31, 2017
Primary Completion Date
February 21, 2024
Study Completion Date
June 9, 2025
ibrutinib
ibrutinib 560mg administered orally
placebo to match ibrutinib
placebo capsules to match ibrutinib administered orally
rituximab
rituximab 375mg/m\^2 IV
Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár
Azienda Sanitaria Ospedaliera S. Croce e Carle, Cuneo
Centre Hospitalier de Perigueux, Périgueux
Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST, Meldola
Southern Cancer Center, Mobile
City of Hope, Duarte
Sansum Clinic, Santa Barbara
UCLA Hematology/Oncology, Santa Monica
Helen F. Graham Cancer Center and Research Institute, Newark
SCRI Florida Cancer Specialists South, Fort Myers
Florida Cancer Affiliates, Ocala
SCRI Florida Cancer Specialists North, St. Petersburg
Rush University Medical Center, Chicago
Norton Cancer Institute, Louisville
Goldschmidt Cancer Center, Jefferson City
Southeast Nebraska Cancer Center, Lincoln
OHSU Knight Cancer Institute Beaverton Clinic, Beaverton
Greenville Health System, Greenville
SCRI Tennessee Oncology Chattanooga, Chattanooga
SCRI Tennessee Oncology Nashville, Nashville
Texas Oncology (Medical City), Dallas
Texas Oncology-Dallas Presbyterian Hospital, Dallas
SCRI The Center For Cancer and Blood Disorders, Fort Worth
MD Anderson Cancer Center, Houston
Texas Oncology (Tyler), Tyler
Oncology and Hematology Associates of Southwest Virginia (Blacksburg), Blacksburg
Swedish Cancer Institute, Seattle
Medical Oncology Associates, Spokane
W VA University Mary Babb Randolph Cancer Center, Morgantown
The Canberra Hospital, Garran
Mater Misericordiae Health Services, South Brisbane
Royal Hobart Hospital, Hobart
Monash Medical Centre Clayton Campus, Clayton
Andrew Love Cancer Center, Geelong
Universitätsklinikum Innsbruck, Innsbruck
Uniklinikum Salzburg, Salzburg
Cliniques Universitaires Saint-Luc, Brussels
ZNA Stuivenberg, Antwerp
AZ Sint-Jan Brugge Oostende AV, Bruges
UZ Gent, Ghent
CHU de Liège, Liège
AZ Nikolaas, Sint-Niklaas
Gasthuis Zusters Antwerpen, Wilrijk
Moncton Hospital, Moncton
CHUM Notre Dame Hospital, Montreal
CIUSSS-de-l'Est-de-l'Île-de-Montréal, Montreal
Fakultni nemocnice Hradec Kralove, Hradec Králové
Fakultni nemocnice Ostrava, Ostrava
Fakultni nemocnice Kralovske Vinohrady, Prague
Fakultni nemocnice v Motole, Prague
Centre Hospitalier de Valence, Valence
CHRU de Poitiers La Miletrie, Poitiers
CHU de Limoges Hôpital Dupuytren, Limoges
CHU Bordeaux, Pessac
Hôpital Civil, Strasbourg
University General Hospital of Patras, Pátrai
Laiko General Hospital of Athens, Athens
University General Hospital of Larissa, Larissa
Országos Onkológiai Intézet, Budapest
Debreceni Egyetem Klinikai Kozpont, Debrecen
Petz Aladár Megyei Oktató Kórház, Győr
Pécsi Tudományegyetem, Pécs
Barzilai Medical Center, Ashkelon
Bnei Zion Medical Center, Haifa
Lady Davis Carmel Medical Center, Haifa
Rabin Medical Center Beilinson Campus, Petah Tikva
Assuta Medical Center, Tel Aviv
Assaf Harofe Medical Center, Ẕerifin
Ospedale Infermi di Rimini, Rimini
Ospedale Policlinico San Martino, Genoa
Istituto Europeo Di Oncologia, Milan
Azienda Ospedaliera Città della Salute e della Scienza di Torino, Turin
Azienda ospedaliera Universiataria Senese, Siena
Centro Di Riferimento Oncologico, Aviano
San Raffaele Scientific Institute, Milan
ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda Ca' Granda, Milan
Azienda Ospedaliero Universitaria di Parma, Parma
Farmacia Polo Ematologico Policlinico Umberto I, Roma
Policlinico Universitario Campus Biomedico di Roma, Roma
Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino
Gelre Ziekenhuizen, Apeldoorn
Maasstad Ziekenhuis, Rotterdam
Leids Universitair Medisch Centrum, Leiden
ETZ-Elisabeth, Tilburg
Centrum Onkologii Ziemi Lubelskiej, Lublin
Copernicus PL Sp. z o.o. Wojewodzkie Centrum Onkologii, Gdansk
Szpitale Pomorskie Sp. z o. o., Gdynia
Malopolskie Centrum Medyczne, Krakow
Samodzielny Publiczny Szpital Kliniczny Nr 1 we Wroclawiu, Wroclaw
Unidade Local de Saúde de Matosinhos SA, Matosinhos Municipality
Centro Hospitalar do Porto - Hospital de Santo António, Porto
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe, Porto
Regional Clinical Hospital, Krasnoyarsk
Russian Oncology Research Center n a N N Blokhin, Moscow
Nizhegorodskaya Regional Clinical Hospital n.a. Semashko, Nizhny Novgorod
City Hospital #31, Saint Petersburg
North-West Federal Medical Research Center n.a. V.A. Almazov, Saint Petersburg
Hospital de Cabueñes, Gijón
Hospital Universitario Virgen de Valme, Seville
Hospital del Mar, Barcelona
Hospital Universitario Germans Trias i Pujol, Barcelona
Hospital Vall dHebron, Barcelona
ICO L'Hospitalet, Barcelona
Hospital Universitario HM Sanchinarro - CIOCC, Madrid
Hospital Universitario Infanta Leonor, Madrid
Hospital Universitario La Paz, Madrid
Hospital Arnau de Vilanova, Valencia
Hospital Clinico Universitario de Valladolid, Valladolid
Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City
Kaohsiung Medical University Hospital, Kaohsiung City
Chi Mei Medical Center, Liouying, Liuying
National Taiwan University Hospital, Taipei
Taipei Veterans General Hospital, Taipei
Gazi Universitesi Tip Fakultesi Hastanesi, Ankara
Ege Universitesi Tip Fakultesi Hastanesi, Bornova
Mersin Universitesi Tip Fakultesi Hastanesi, Gaziantep
Erciyes Universitesi Tip Fakultesi Hastanesi, Kayseri
Kocaeli Universitesi Tip Fakultesi Arastirma ve Uygulama Hastanesi, Kocaeli
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi, Samsun
Namik Kemal Universitesi Tip Fakultesi Hastanesi, Tekirdağ
Norfolk and Norwich University Hospital, Norwich
Addenbrooke's Hospital, Cambridge
Leeds Teaching Hospitals NHS Trust, Leeds
Barts and The London NHS Trust, London
Derriford Hospital, Plymouth
Royal Berkshire Hospital NHS Foundation Trust, Reading
Centro Hospitalar de São João, E.P.E., Porto
Royal Cornwall Hospital - Hospital Treliske, Tururo
Lead Sponsor
Pharmacyclics LLC.
INDUSTRY