380
Participants
Start Date
June 14, 2017
Primary Completion Date
April 30, 2027
Study Completion Date
August 31, 2028
Standard TME surgery
Total mesorectal excision
Long course concurrent chemoradiation with capecitabine and radiotherapy
Capecitabine 825 mg/m² orally, b.i.d., on radiotherapy days. Radiotherapy: A dose of 50 Gy, applied to the primary tumour and surrounding mesorectum, in 25 fractions of 2 Gy, 5 days a week.
Short course radiotherapy
A dose of 25Gy, applied, to the primary tumour and surrounding mesorectum in 5 fractions of 5 Gy, 5 days a week.
University Hospital UZ Leuven, Leuven
Odense University Hospital, Odense
Radboud University medical center, Nijmegen
Region Stockholm, Onkologkliniken Södersjukhuset AB, Stockholm
University of Birmingham, Birmingham
University of Birmingham
OTHER