Safety and Effectiveness of A-dmDT390-bisFv(UCHT1) Fusion Protein in Subjects With Mycosis Fungoides

PHASE2UnknownINTERVENTIONAL
Enrollment

162

Participants

Timeline

Start Date

January 31, 2017

Primary Completion Date

December 31, 2018

Study Completion Date

May 31, 2020

Conditions
Mycosis Fungoides
Interventions
BIOLOGICAL

A-dmDT390-bisFv(UCHT1)

anti-T cell immunotoxin (antibody targeting CD3 on T-cells tagged with diphtheria toxin without binding domain)

DRUG

Vorinostat

ZOLINZA is a histone deacetylase (HDAC) inhibitor indicated for the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma (CTCL) who have progressive, persistent or recurrent disease on or following two systemic therapies.

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

City of Hope National Medical Center

OTHER

collaborator

Columbia University

OTHER

collaborator

Dana-Farber Cancer Institute

OTHER

collaborator

Northwestern University Feinberg School of Medicine

OTHER

collaborator

H. Lee Moffitt Cancer Center and Research Institute

OTHER

collaborator

Ohio State University Comprehensive Cancer Center

OTHER

collaborator

Rush University Medical Center

OTHER

collaborator

Scott and White Hospital & Clinic

OTHER

collaborator

Yale University

OTHER

collaborator

Stanford University

OTHER

collaborator

Thomas Jefferson University

OTHER

collaborator

University of Arkansas

OTHER

collaborator

University of Colorado, Denver

OTHER

collaborator

University of Texas Southwestern Medical Center

OTHER

collaborator

University of Washington

OTHER

collaborator

Vanderbilt University School of Medicine

OTHER

collaborator

Washington University School of Medicine

OTHER

lead

Angimmune LLC

INDUSTRY

NCT02943642 - Safety and Effectiveness of A-dmDT390-bisFv(UCHT1) Fusion Protein in Subjects With Mycosis Fungoides | Biotech Hunter | Biotech Hunter