Efficacy and Safety of Artemisinin-based Combination Treatments in the Democratic Republic of the Congo

PHASE4CompletedINTERVENTIONAL
Enrollment

1,615

Participants

Timeline

Start Date

March 15, 2017

Primary Completion Date

January 2, 2018

Study Completion Date

January 2, 2018

Conditions
Malaria
Interventions
DRUG

artesunate-amodiaquine

Tablets containing 25 mg of artesunate and 67.5 mg of amodiaquine: one tablet daily for three days children weighing 4.5 to 8 kg, and tablets containing 50 mg of artesunate and 135 mg of amodiaquine: one tablet daily for three days for children weighing 9 to 17 kg.

DRUG

artemether-lumefantrine

"Tablets containing 20 mg of Artemether and 120 mg of Lumefantrine. Each dose to be taken with high-fat food or drinks (for example milk).~One tablet twice daily for children weighing 5 to \<15 kg, two tablets twice daily for those weighing 15 to \<25 kg and three tablets twice daily for those weighing 25 to \< 35 kg, for three days."

DRUG

Dihydroartemisinine-piperaquine

Tablets containing 20 mg of dihydroartemisinine and 160 mg of piperaquine. Half a tablet once daily for children weighing 5 to \<7 kg, one tablet once daily for those weighing 7 to \<13 kg, and two tablets once daily for those weighing 13 to \<24 kg, for three days.

Trial Locations (6)

Unknown

Centre Evangélique de Coopération, Kimpese

Centre de Santé Lupidi 1, Kapolowe

Centre de Santé de Référence Mikalayi, Kazumba

Centre de Santé de Référence Rutshuru, Rutshuru

Centre de Santé Foyer Social, Kabondo

Centre de santé Bolenge, Bolenge

All Listed Sponsors
lead

Ministry of Public Health, Democratic Republic of the Congo

OTHER_GOV

NCT02940756 - Efficacy and Safety of Artemisinin-based Combination Treatments in the Democratic Republic of the Congo | Biotech Hunter | Biotech Hunter