Testing the Safety and Efficacy of the Combination of the Antibody Pembrolizumab and Entinostat in Patients With Myelodysplastic Syndrome Who Are Not Responding to Hypomethylating Agents

PHASE1CompletedINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

June 23, 2017

Primary Completion Date

November 4, 2022

Study Completion Date

February 12, 2025

Conditions
Myelodysplastic Syndrome
Interventions
DRUG

Entinostat

Given PO

BIOLOGICAL

Pembrolizumab

Given IV

Trial Locations (19)

20007

MedStar Georgetown University Hospital, Washington D.C.

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

Duke University Medical Center, Durham

40536

University of Kentucky/Markey Cancer Center, Lexington

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

University of Chicago Medicine-Orland Park, Orland Park

60611

Northwestern University, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Clinical Research Center, Fairway

University of Kansas Hospital-Westwood Cancer Center, Westwood

68118

Nebraska Medicine-Village Pointe, Omaha

68198

University of Nebraska Medical Center, Omaha

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT02936752 - Testing the Safety and Efficacy of the Combination of the Antibody Pembrolizumab and Entinostat in Patients With Myelodysplastic Syndrome Who Are Not Responding to Hypomethylating Agents | Biotech Hunter | Biotech Hunter