172
Participants
Start Date
June 30, 2016
Primary Completion Date
August 17, 2018
Study Completion Date
January 31, 2019
Celecoxib
Dosing will be 6mg/kg twice a day with a maximum dose of 300mg twice a day. All ages will be given the suspension (concentration 100mg/5mL) orally
Placebo
Placebo will have the same appearance, taste and consistency as celecoxib. Placebo will consist of calcium carbonate powder suspended in the same syrup as celecoxib. Dose of elemental calcium is 3 mg/kg/day.
Acetaminophen
Acetaminophen syrup at a dose of 15mg/kg/dose will be given every 4 hours for the first 5 days after surgery. After that point, is given as needed.
Oxycodone
Oxycodone may be used every 4 hours post-operatively to treat breakthrough pain. The most commonly prescribed dose is 0.075mg/kg/dose (suspension) every 4 hours as needed.
Children's Hospital of Philadelphia, Philadelphia
Collaborators (1)
Pfizer
INDUSTRY
Children's Hospital of Philadelphia
OTHER