Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

702

Participants

Timeline

Start Date

October 13, 2016

Primary Completion Date

February 11, 2019

Study Completion Date

November 10, 2022

Conditions
BRAF V600E-mutant Metastatic Colorectal Cancer
Interventions
DRUG

Encorafenib

Orally, once daily.

DRUG

Binimetinib

Orally, twice daily.

DRUG

Cetuximab

Standard of care.

DRUG

Irinotecan

Standard of care.

DRUG

Folinic Acid

Standard of care.

DRUG

5-Fluorouracil

Standard of care.

Trial Locations (418)

333

Chang Gung Memorial Hospital, Linkou, Taoyuan

500

Changhua Christian Hospital, Changhua

704

National Cheng Kung University Hospital, Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

1010

DZU, Diagnose Zentrum Urania GmbH, Vienna

1032

Szent Margit Kórház, Budapest

1062

Eszak-Pesti Centrumkorhaz-Honvedkorhaz, Budapest

Magyar Honvedseg Egeszsegugyi Kozpont, Budapest

1090

AKH Wien, Vienna

Medizinische Universitaet Wien/AKH Wien, Vienna

Medizinische Universität Wien/AKH Wien, Vienna

1097

Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet, Budapest

1145

Uzsoki Utcai Korhaz, Budapest

1350

Colosseum Øyelegesenter C/O LB Holdings AS, Lommedalen

2010

St Vincent's Clinic, Darlinghurst

St Vincent's Hospital Sydney, Darlinghurst

2150

Marsden Eye Specialists, Parramatta

2300

Newcastle Eye Centre, Sydney

2650

UZ Antwerpen, Edegem

2700

CLINICA PERGAMINO S.A. (Centro de Investigacion Pergamino S.A.), Pergamino

2820

Imelda Ziekenhuis, Bonheiden

3000

Peter MacCallum Cancer Centre, Melbourne

University Hospital Gasthuisberg (UZ Leuven), Leuven

3084

Austin Health, Heidelberg

3168

Monash Health Translation Precinct - Monash Health, Clayton

4000

Centre Hospitalier Universitaire (CHU) de Liege, Liège

CHC Saint Joseph, Liège

4032

Debreceni Egyetem Klinikai Kozpont, Debrecen

4101

Mater Misericordiae Limited, South Brisbane

4600

Klinikum Wels - Grieskirchen GmbH, Abteilung fuer Innere Medizin IV, Wels

Klinikum Wels-Grieskirchen GmbH, Abteilung fuer Augenheilkunde und Optometrie, Wels

Klinikum Wels-Grieskirchen GmbH, Abteilung fuer Innere Medizin II, Wels

Klinikum Wels-Grieskirchen GmbH, Institut fuer Nuklearmedizin, Wels

Klinikum Wels-Grieskirchen GmbH, Institut fuer Radiologie I, Wels

4800

Centre Hospitalier Regional (CHR) - Verviers, Verviers

5000

Central Adelaide Local Health Network Inc. operating as Royal Adelaide Hospital, Adelaide

5011

Central Adelaide Local Health Network Inc. operating as The Queen Elizabeth Hospital, Woodville South

5042

Flinders Medical Centre, Bedford Park

5300

Centro Oncologico Riojano Integral - CORI, La Rioja

6000

Grand Hopital de Charleroi (GHdC), Charleroi

6800

Centre Hospitalier de l'Ardenne - Site de Libramont, Libramont-Chevigny

7624

Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar, Pécs

Pecsi Tudomanyegyetem Klinikai Kozpont, Pécs

8000

AZ Sint-Jan Brugge - Oostende AV - Campus Sint-Jan - Oncology, Bruges

8800

AZ Delta Roeselaere-Menen, Roeselaere

9000

AZ Maria Middelares, Ghent

10002

National Taiwan University Hospital, Taipei

10065

Memorial Sloan Kettering Cancer Center, New York

Memorial Sloan Kettering: Rockefeller Outpatient Pavilion, New York

11725

Memorial Sloan Kettering: Commack, Commack

13589

Evangelisches Waldkrankenhaus Spandau, Berlin

13620

Seoul National University Bundang Hospital, Seongnam-si

14004

Hospital Universitario Reina Sofía, Córdoba

14008

Consulta Dr. Juan Carlos Castillo Dominguez, Córdoba

14068

Hallym University Sacred Heart Hospital, Anyang

14612

Augenarzt-Gemeinschaftspraxis Dr.med.Andreas Kind & Dr.med. Ute Kariger-Schweigert, Falkensee

16059

Uludag University Hospital, Bursa

16499

Ajou University Hospital, Suwon

20089

U.O. Oculistica, Istituto Clinico HUMANITAS, Rozzano

U.O. di Oncologia ed Ematologia, Istituto Clinico HUMANITAS, Rozzano (MI)

20132

IRCCS Ospedale San Raffaele - U.O. di Medicina Oncologica, Milan

Servizio di Farmacia - IRCCS Ospedale San Raffaele, Milan

20133

S.C. Radiologia diagnostica e interventistica - Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

SC Oncologia Medica 1, SS Oncologia Medica Gastroenterologica, Milan

20141

Radiologia, Milan

Unita di Oncologia Medica Gastrointestinale e Tumori Neuroendocrini, Milan

20162

Grande Ospedale Metropolitano Niguarda, Milan

20246

Universitaetsklinikum Hamburg Eppendorf, Klinik fuer Augenheilkunde, Hamburg

20249

Facharztzentrum Eppendorf, Hamburg

20251

Universitaetsklinikum Hamburg Eppendorf, Zentrum fuer Radiologie und Endoskopie, Hamburg

21029

Vinnytskyi oblasnyi klinichnyi onkolohichnyi dyspanser, viddilennia khimioterapii, Vinnytsia

21287

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

The Investigational Drug Pharmacy (IDS) in the Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

21565

Gachon University Gil Medical Center, Incheon

22030

Trakya Universitesi Tip Fakultesi, Edirne

22045

ZytoService Deutschland GmbH, Standort-Hamburg-Jenfeld, Hamburg

22297

HKS Kardiologische Praxis am Israelitischen Krankenhaus, Hamburg

Radiologie im Israelitischen Krankenhaus, Hamburg

23007

Complejo Hospitalario de Jaen, Jaén

Sercosa - Clinica de las Nieves, Jaén

24047

ASST Bergamo Ovest, Ospedale Treviglio Caravaggio di Trevigl, Treviglio

24127

Oculistica, ASST Papa Giovanni XXIII, Bergamo

Oncologia, ASST Papa Giovanni XXIII, Bergamo

25030

Hopital Jean Minjoz, Besançon

26100

Oculistica - ASST Cremona, Ospedale di Cremona, Cremona

SC Farmacia Aziendale - ASST Cremona, Ospedale di Cremona, Cremona

SC Oncologia - ASST Cremona, Ospedale di Cremona, Cremona

28006

Hospital Nuestra Señora del Rosario, Madrid

Gabinete Radiologico Dr. Pita, Madrid

28007

Hospital General Universitario Gregorio Maranon, Madrid

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Clinico San Carlos, Madrid

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28050

Hospital HM Universitario Sanchinarro, Madrid

29609

CHU Morvan, Brest

30625

Medizinische Hochschule Hannover (MHH), Hanover

Medizinische Hochschule Hannover, Hanover

31057

CHU Toulouse - Purpan, hopital Pierre-Paul Riquet, Toulouse

31059

CHU Toulouse-Institut Inuversitaire du Cancer Toulouse, Toulouse

CHU Toulouse-Rangueil, Toulouse

32224

Mayo Clinic Florida, Jacksonville

33136

Sylvester Comprehensive Cancer Center/UMHC, Miami

33146

The Lennar Foundation Medical Center, Coral Gables

33176

Sylvester at Kendall, Miami

33316

Broward Health Medical Center, Fort Lauderdale

Dr. Clayton Berger (opthalmology), Fort Lauderdale

Mehmet F. Hepgur, MD - Broward Health Medical Center, Fort Lauderdale

34298

ICM Val d'Aurelle, Montpellier

34430

SCM Centre d'ophtalmologie, Saint Jeand de Vedas

34722

Medeniyet University Goztepe Training and Research Hospital, Istanbul

35040

Ege University Medical Faculty, Izmir

35128

Cardiologia per i pazienti oncologici - Istituto Oncologico Veneto I.R.C.C.S, Padua

Clinica Oculistica - Azienda Ospedaliera di Padova, Padua

U.O. Oncologia Medica 1 - Istituto Oncologico Veneto I.R.C.C.S, Padua

35136

Kliniken Essen Mitte / Knappschaftskrankenhaus, Essen

35575

Izmir Medical Park Hospital - Medical Oncology, Izmir

37232

Henry-Joyce Cancer Clinic, Nashville

Vanderbilt Eye Institute, Nashville

40138

Policlinico S.Orsola Malpighi, AOU di Bologna - Oncologia Medica, Bologna

40447

China Medical University Hospital, Taichung

41013

Hospital Universitario Virgen del Rocio, Seville

41063

Augentagesklinik Maria-Hilf Krankenhaus, Mönchengladbach

Kliniken Maria Hilf GmbH - Franziskuskrankenhaus, Mönchengladbach

Kliniken Maria Hilf GmbH; Klinik fuer Radiologie, Mönchengladbach

41100

"Oftalmolohycheskyi tsentr Vzghliad MTs", Dnipropetrovsk

41124

Dipartimento Interaziendale Farmaceutico - AOU Policlinico di Modena, Modena

SC di Oftalmologia - AOU Policlinico di Modena, Modena

SC di Radiologia, Dipartimento Interaziendale integrato Diagnostica per Immagini, Modena

SSD Day Hospital Oncologico - Dipartimento ad attivita integrata di Oncologia, Ematologia, Modena

41464

Lukaskrankenhaus Neuss; Zentrale Apotheke, Neuss

43204

Hospital Universitari Sant Joan de Reus, Reus

44093

CHU HOTEL-Dieu, Nantes

44195

Cleveland Clinic Taussig Cancer Institute, Cleveland

44280

Inonu Universitesi Turgut Ozal Medical Center, Malatya

44718

Gabrail Cancer Center Research, Canton

44789

Institut f. Pathologie - Ruhr-Universitaet Bochum, Prof. Dr. med. Andrea Tannapfel, Bochum

45131

Praxis fuer Augenheilkunde Dr. Edmund Meyer-Schwickerath, Essen

45136

Kliniken Essen-Mitte, Essen

45147

Universitaetsklinikum Essen (AoeR), Innere Klinik (Tumorforschung), Westdeutsches Tumorzentrum, Essen

Universitaetsklinikum Essen; Diagnostischeu. Interventionelle Radiologie u. Neuroradiologie, Essen

Universitaetsklinikum Essen; Nuklearmedizin, Essen

Universitaetsklinikum Essen; Zentralapotheke, Essen

45239

Evang. Krankenhaus Essen - Werden; Klinik fuer Augenheilkunde, Essen

45276

Kliniken Essen Mitte / Knappschaftskrankenhaus, Essen

46004

Clinica Oftalvist, Valencia

46009

Fundacion Instituto Valenciano de Oncologia, Valencia

46010

Hospital Clinico Universitario de Valencia, Valencia

46014

Hospital General Universitario de Valencia, Valencia

46202

Indiana University Health Hospital, Indianapolis

Indiana University Health Melvin and Bren Simon Cancer Center, Indianapolis

Investigational Drug Services IUHSCC, Indianapolis

Sidney &Lois Eskenazi Hospital, Indianapolis

46290

IU Health Springmill, Indianapolis

47150

Baptist Health Floyd Cancer Center, New Albany

49027

"Oftalmolohycheskyi tsentr Vzghliad MTs", Dnipropetrovsk

49102

Derzhavnyi zaklad, Dnipropetrovska medychna akademiia Ministerstva okhorony zdorovia Ukrainy, Dnipropetrovsk

Komumalnyi zaklad, Dnipropetrovska miska bahatoprofilna klinichna likarnia Nº4, Dnipropetrovsk

49201

Dong-A University Hospital, Busan

50006

Hospital Quiron Salud Zaragoza, Zaragoza

50009

Hospital Universitario Miguel Servet, Zaragoza

50134

"Dipartimento Neuromuscoloscheletrico e Organi di Senso, Oncologia Oculare Unit", Florence

SC oncologia Medica I - Azienda Ospedaliero Universitaria Careggi, Florence

51092

CHU Robert Debre, Reims

52242

University of Iowa Hospitals and Clinics, Iowa City

53792

University of Wisconsin Clinical Science Center, Madison

55905

Mayo Clinic, Rochester

56124

UO Oculistica - AOU Pisana, Stabilimento Ospedaliero di Cisanello, Pisa

56126

SOD Radiodiagnostica 3 - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara, Pisa

UO Farmaceutica, Gestione del Farmaco - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara, Pisa

UO Oncologia Medica 2 - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara, Pisa

58128

Chonnam National University Hwasun Hospital, Hwasun-gun

60020

Ospedali Riuniti Umberto I, Torrette Di Ancona

60451

University of Chicago Comprehensive Cancer Center at Silver Cross Hospital, New Lenox

60462

The University of Chicago Medicine Center for Advanced Care Orland Park, Orland Park

60637

University of Chicago Medical Center, Chicago

61350

Illinois CancerCare- Ottawa, Ottawa

61401

Illinois CancerCare- Galesburg, Galesburg

61495

NZOZ Przychodnia Specjalistyczna GUTMED, Poznan

61615

Illinois Cancer Care, PC, Peoria

Illinois Eye Center, Peoria

61704

Illinois CancerCare- Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

63104

SSM Health Saint Louis University Hospital, St Louis

63110

Barnes Jewish Hospital, St Louis

Saint Louis University, St Louis

SSM Health Saint Louis University Hospital, St Louis

Washington University Infusion Center Pharmacy, St Louis

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center - South County, St Louis

63141

Siteman Cancer Center - West County, Creve Coeur

63376

Siteman Cancer Center - St Peters, City of Saint Peters

66160

The University of Kansas Hospital, Kansas City

66205

The University of Kansas Clinical Research Center, Fairway

The University of Kansas Cancer Center and Medical Pavilion, Westwood

The University of Kansas Cancer Center, Investigational Drug Services, Westwood

66208

KU Eye, Prairie Village

67547

Augenarzt Praxis Dr. med. Petra Huelsmann, Worms

Gemeinschaftspraxis fuer Radiologie und Nuklearmedizin, Standort Worms, Worms

Martin Apotheke, Worms

Onkologische Schwerpunktpraxis Worms, Worms

Praxisgemeinschaft Kruse + Hofstaetter, Worms

69130

Centre Ophtalmologique - Pole Vision - Clinique Val d'Ouest, Écully

69373

Centre Leon Berard, Lyon

70121

Ochsner Clinic Foundation, New Orleans

72076

Universitaetsklinikum Tuebingen, Tübingen

75015

Hopital Georges Pompidou, Paris

75571

Centre hospitalier national d'ophtalmologie des Quinze-Vingts, Paris

Centre Hospitalier National d'Opthalmologie des Quinze-Vingts (CHNO des XV-XX), Paris

76504

Scott & White Clinic - Temple Pavilion, Temple

76508

Scott & White Medical Center - Temple, Temple

80045

Rocky Mountain Lions Eye Institute, Aurora

University of Colorado Cancer Center - Anschutz Cancer Pavilion, Aurora

University of Colorado Denver CTO (CTRC), Aurora

University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP), Aurora

University of Colorado Hospital Inpatient Pavillion', Aurora

80131

AOU Universita degli Studi della Campania L. Vanvitelli - DAI di Medicina Interna e Specialistica, Napoli

AOU Universita degli Studi della Campania L. Vanvitelli - U. Ma.Ca., Napoli

AOU Universita degli Studi della Campania L. Vanvitelli, Napoli

80138

AOU Universita degli Studi della Campania L. Vanvitelli, Napoli

80336

Augenklinik der Universitaet Muenchen, Munich

81377

LMU Klinikum der Universitaet Muenchen, Campus Grosshadern, Munich

85054

Mayo Clinic Hospital, Phoenix

Mayo Clinic, Phoenix

85259

Mayo Clinic, Scottsdale

88000

"DVNZ Uzhhorodskyi natsionalnyi universytet", Uzhhorod

"TOV Zakarpatskyi Tsentr Mikrokhirurhii Oka", Uzhhorod

Tsentralna miska klinichna likarnia, Miskyi onkolohichnyi tsentr, Uzhhorod

89081

Universitaetsklinikum Ulm, Ulm

90033

Keck Hospital of USC - Norris Healthcare Center (HC3), Los Angeles

Keck Hospital of USC, Los Angeles

LAC+USC Medical Center, Los Angeles

Norris Healthcare Center 3 (HC3), Los Angeles

USC Eye Institute, Los Angeles

USC/Norris Comprehensive Cancer Center, Los Angeles

91010

City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte

91240

Mt. Scopus Department of Medical Imaging of Hadassah Medical Organization,, Jerusalem

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

92708

Compassionate Care Research Group, Inc. at Compassionate Cancer Care Medical Group, Inc., Fountain Valley

92868

Harvard Eye Associates, Orange

94805

Gustave Roussy, Villejuif

97239

Casey Eye Institute-South Waterfront, Portland

OHSU Center for Health and Healing, Portland

OHSU Research Pharmacy Services, Portland

Oregon Health and Science University, Portland

99204

Spokane Eye Clinic, Spokane

99208

Inland Imaging, LLC Holy Family Hospital, Spokane

Medical Oncology Associates, PS DBA Summit Cancer Centers, Spokane

Providence Holy Family Nuclear Medicine, Spokane

99216

Medical Oncology Associates, PS DBA Summit Cancer Centers, Spokane Valley

115478

"Federal State Budget Institution N.N. Blokhin Russian Cancer Research Center of the", Moscow

"Federal State Budget Institution N.N. Blokhin Russian Cancer Research Center", Moscow

197022

State Budgetary Educational Institution of Higher Professional Education First Saint Petersburg, Saint Petersburg

249036

A. Tsyb Medical Radiological Research Center - branch of the, Obninsk

305524

Regional Budgetary Healthcare Institution Kursk Regional Clinical, Kursk

454048

Evimed Llc, Chelyabinsk

2520612

Hospital Clinico Vina Del Mar, Viña del Mar

4428164

Imaging Department of Meir Medical Center, Kfar Saba

Meir Medical Center, Kfar Saba

4810469

Instituto Clinico Oncologico del Sur (ICOS), Temuco

4941492

Pharmacy of Rabin Medical Center, Beilinson Hospital, Petah Tikva

Rabin Medical Center, Beilinson Hospital, Petah Tikva

5126413

MOR Institute, Bnei Brak

5262100

The Chaim Sheba Medical Center, Tel Litwinsky

6423906

Tel Aviv Sourasky Medical Center - Oncology, Tel Aviv

7830604

The Barzilai Medical Center - Oncology Institute, Ashkelon

8410101

Soroka University Medical Center, Beersheba

9112001

Ein-Karem Department of Medical Imaging of Hadassah Medical Organization, Hadassah Medical Center,, Jerusalem

Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem, Jerusalem

Pharmacy of Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem, Jerusalem

06510

Smilow Cancer Hospital at Yale - New Haven, New Haven

Temple Medical Center, New Haven

06520

Yale University, Yale Cancer Center, New Haven

06473

Smilow Cancer Hospital Care Center at North Haven, North Haven

02114

Massachusetts General Hospital, Boston

Ophthalmic Consultants of Boston Inc, Boston

02115

Brigham & Women's Hospital, Boston

02215

Dana-Farber Cancer Institute (DFCI), Boston

Dana-Farber Cancer Institute, Boston

07920

Memorial Sloan Kettering: Basking Ridge, Basking Ridge

77030-4009

The University of Texas MD Anderson Cancer Center, Houston

L6300EAN

Centro Medico INFINITO, Santa Rosa

T4000GTB

Centro Medico CAIPO (Centro para la Atención del paciente Oncológico), San Miguel de Tucumán

X5004FHP

Clinica Universitaria Reina Fabiola, Córdoba

29300-045

CEMES Centro Medico Especializado em Oftalmologia, Cachoeiro de Itapemirim

29308-014

Centro de Pesquisas Clínicas em Oncologia, Cachoeiro de Itapemirim

29308-055

Hospital Evangelico de Cachoeiro de Itapemirim, Cachoeiro de Itapemirim

41820-020

Hospital do Olho, Salvador

41820-021

CENOB - Centro de Oncologia da Bahia SS Ltda / Oncovida, Salvador

30110-921

Instituto Vizibelli, Belo Horizonte

30130-090

CENANTRON - Centro Avancado de Tratamento Oncologic, Belo Horizonte

95070-560

Fundação Universidade de Caxias do Sul, Caxias do Sul

95900-000

Daniel Lubisco Pandolfi, Lajeado

Sociedade Beneficencia e Cardade de Lajeado/Hospital Bruno Born, Lajeado

95900-010

Sociedade Beneficencia e Cardade de Lajeado/Hospital Bruno Born, Lajeado

99010-080

Associacao Hospitalar Beneficente Sao Vicente de Paulo / Hospital Sao Vicente de Paulo, Passo Fundo

Consultorio Medico de Oftalmologia - Dr. Ricardo Tres, Passo Fundo

99010-090

Hospital Sao Vicente de Paulo, Passo Fundo

96010-140

Thiago Vernetti Ferreira, Pelotas

96015-280

Leandro Becker, Pelotas

96020-080

Fernanda Mendes, Pelotas

UPCO - Unidade de Pesquisas Clinicas em Oncologia, Pelotas

96020-260

Fernanda Lauermann, Pelotas

90020-013

Diogo Duarte Torre, Porto Alegre

90020-090

Farmacia Central da Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre

Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre

90050-170

Nucleo de Novos Tratamentos em Cancer, Porto Alegre

90110-270

Centro de Pesquisa Clínica de Oncologia e Hematologia - Hospital Mãe de Deus/AESC, Porto Alegre

90470-340

Clinica de Oftalmologia Lavinsky, Porto Alegre

90880-480

Hospital Mãe de Deus, Porto Alegre

88301-220

Giuliano Santos Borges - ME / Clinica de Neoplasias Litoral - Centro de Novos Tratamentos Itajai, Itajaí

14780-110

Clinica Toller, Barretos

14780-300

Olhos Centro Diagnostico e Laser LTDA, Barretos

14784-400

Fundacao Pio XII, Barretos

09060-650

FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC, Santo André

09060-870

FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC, Santo André

15090-000

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, São José do Rio Preto

18030-075

CEPOS - Centro de Estudos e Pesquisas Oncologicas de Sorocaba, Sorocaba

18030-200

"Instituto de Oncologia de Sorocaba Dr. Gilson Delgado", Sorocaba

18040-425

Karen Miyuki Kubokawa Shorer, Sorocaba

18047-620

Oftalmologia Diagnostica de Sorocaba (ODS), Sorocaba

01236-030

Instituto de Ensino e Pesquisa São Lucas, São Paulo

01242-020

Instituto de Ensino e Pesquisa São Lucas - Pharmacy, São Paulo

01507-000

Hospital Leforte, São Paulo

04038-020

IPEPO - Instituto da Visao, São Paulo

V5Z 3N9

Eye Care Centre, Vancouver General Hospital, Vancouver

V5Z 4E6

BC Cancer, Vancouver Center, Vancouver

K1H 8L6

The Ottawa Hospital Cancer Centre, Ottawa

M4N 3M5

Sunnybrook Research Institute, Toronto

M5G 1X5

Mount Sinai Hospital, Toronto

H3T 1M5

Centre integre universitaire de sante et de services sociaux de l'Ouest-de-l'Ile-de-Montreal, Montreal

603 00

Ocni ordinace Oftalpro s.r.o., Brno

656 53

Masarykuv onkologicky ustav, Brno

500 05

Fakultni nemocnice Hradec Kralove, Hradec Králové

Fingerlanduv ustav patologie, Hradec Králové

I. interni kardioangiologicka klinika, Hradec Králové

Klinika nemoci koznich a pohlavnich, Hradec Králové

Nemocnicni lekarna - Usek klinickych studii, Hradec Králové

Ocni klinika, Hradec Králové

Radiologicka klinika, Hradec Králové

779 00

Fakultni nemocnice Olomouc, I. interni klinika - kardiologicka, Olomouc

Fakultni nemocnice Olomouc, Lekarna, Olomouc

Fakultni nemocnice Olomouc, Olomouc

DK-5000

Odense University Hospital (OUH), Odense C

01307

Universitaetsklinikum Carl Gustav Carus der Technischen Universitaet Dresden, Dresden

H-8900

Zala Megyei Szent Rafael Korhaz - Onkologiai Osztaly, Zalaegerszeg

09042

Clinica di Oncologia Medica AOU di Cagliari Presidio Duilio Casula Monserrato, Monserrato

Farmacia AOU di Cagliari Presidio Duilio Casula Monserrato, Monserrato

Radiologia AOU di Cagliari Presidio Duilio Casula Monserrato, Monserrato

09124

Divisione Anatomia Patologica Presidio San Giovanni di Dio, Cagliari

Oculistica AOU di Cagliari Presidio San Giovanni di Dio, Cagliari

00133

U.O.S.D. Oncologia Medica, Dipartimento di Medicina - Fondazione PTV Policlinico Tor Vergata, Roma

U.O.S.D. Patologie Retiniche - Fondazione PTV Policlinico Tor Vergata, Roma

464-0092

Chayagasaka Eye Clinic, Nagoya

464-8681

Aichi Cancer Center Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa-shi

060-8648

Hokkaido University Hospital, Sapporo

920-8641

Kanazawa University Hospital, Kanazawa

216-8511

St. Marianna University School of Medicine Hospital, Kawasaki

241-0821

Tsukahara Eye Clinic, Yokohama

241-8515

Kanagawa Cancer Center, Yokohama

565-0871

Osaka University Hospital Laboratory for Clinical Investigation, Suita

104-0045

National Cancer Center Hospital, Chuo-ku

811-1395

National Hospital Organization Kyushu Cancer Center, Fukuoka

815-8588

Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka

540-0006

National Hospital Organization Osaka National Hospital, Osaka

06760

Consultorio dentro de la Torre Medica Dalinde (Oncologia Medica), Mexico City

Superare Centro de Infusion S.A. de C.V., Delegacion Cuauhtemoc

6815 AD

Rijnstate Hospital Arnhem, Arnhem

6883 AZ

Rijnstate Hospital Velp, Velp

6229HX

Maastricht University Medical Center (MUMC), Maastricht

1066 CX

The Netherlands Cancer Institute, Amsterdam

1091 AC

Onze Lieve Vrouwen Gasthuis, Amsterdam

2545 AA

Haga Ziekenhuis, The Hague

3584 CX

Universitair Medisch Centrum Utrecht, Utrecht

3584CX

Universitair Medisch Centrum Utrecht, Utrecht

0369

Colosseum Øyelegesenter C/O LB Holdings AS, Oslo

0379

Oslo universitetssykehus, Radiumhospitalet, Oslo

Sykehusapoteket Oslo, Radiumhospitalet, Oslo

36-200

Szpital Specjalistyczny W Brzozowie, Podkarpacki Osrodek Onkologiczny Im.Ks.B.Markiewicza, Brzozów

82-300

Wojewodzki Szpital Zespolony, Oddzial Onkologiczny, Elblag

31-826

Szpital Specjalistyczny im. L. Rydygiera w Krakowie Sp.z.o.o., Krakow

05-400

Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina, Otwock

61-485

NZOZ Centrum Medyczne HCP, Poznan

01-748

MAGODENT Sp. z o.o. Szpital Elblaska, Warsaw

08308

Korea University Guro Hospital, Seoul

02841

Korea University Anam Hospital IRB, Seoul

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

07010

Hospital Universitario Son Espases, Palma de Mallorca

08908

Institut Catala d'Oncologia, L'Hospitalet de Llobregat

08208

Hospital Universitari Parc Tauli, Sabadell

08003

Hospital del Mar, Barcelona

08017

Clinica Corachan, Barcelona

08023

Hospital Quiron Salud Barcelona, Barcelona

08029

Cetir Centre Medic S.L., Barcelona

08035

Hospital Universitario Vall d'Hebron, Barcelona

09006

Hospital Universitario de Burgos, Burgos

06230

Hacettepe University Medical Faculty, Ankara

02096

Kyivska klinichna likarnia na zaliznychnomu transporti No3 filii Tsentr okhorony zdorov'ia PAT, Kyiv

Natsionalnyi medychnyi universytet imeni O.O Bohomltsia, kafedra onkolohii, Kyiv

01601

Natsionalnyi medychnyi universytet imeni O.O Bohomltsia, kafedra oftalmolohii, Kyiv

Oleksandrivska klinichna likarnia mista Kyieva, Kyiv

03115

Kyivskyi miskyi klinichnyi onkotsentr, Kyiv

AB25 2ZN

NHS Grampian - Aberdeen Royal Infirmary, Aberdeen

SL4 3DP

King Edward V11 Hospital, Windsor

G12 0YH

Beatson West of Scotland Cancer Centre, Glasglow

B15 2TH

University Hospitals Birmingham NHS Foundation Trust Queen Elizabeth Hospital, Birmingham

W12 0HS

Hammersmith Hospital, Imperial College Healthcare NHS Trust, London

Imperial College Healthcare NHS Trust, Hammersmith Hospital, London

W1G 6AD

Sarah Cannon Research Institute UK, London

W6 8RF

Imperial College Healthcare NHS Trust, Charing Cross Hospital, London

M20 4BX

The Christie NHS Foundation Trust - Christie Hospital, Manchester

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