TIL Therapy for Metastatic Renal Cell Carcinoma

Surgical removal of \> 1 cm3 tumor tissue chosen with regards to high rate of success and to minimize the general risks involved in a surgical procedure.

Cyclophosphamide 60 mg/kg is administered i.v. on day -7 and day -6.

Fludarabine 25 mg/m2 is administered on day -5 to day -1. Maximum dose of 50 mg per administration.

The maximum number of expanded TILs are infused over 30-45 minutes on day 0.

Interleukin-2 is administered as high-dose bolus infusions (600.000 IU/kg) over a 15 minute period every 8 hours and continuing for up to 5 days (maximum of 15 doses).