5,669
Participants
Start Date
December 9, 2016
Primary Completion Date
February 26, 2021
Study Completion Date
February 26, 2021
LCZ696 (sacubitril/valsartan)
LCZ696 (sacubitril/valsartan) tablet will be available in 24/26 mg, 49/51 mg and 97/103 mg, respectively
Ramipril
Ramipril 1.25 mg, 2.5 mg, and 5 mg oral capsules
Placebo of LCZ696
Matching placebo of LCZ696 tablets
Placebo of ramipril
Matching placebo of ramipril capsule
Valsartan
Valsartan (VAL489) 40 mg and 80 mg tablets, two doses for 1 day to patients who were previously treated with ACE inhibitors receiving the last dose of that agent during the last 36 hours prior to randomization
Placebo of valsartan
matching placebo of valsartan for one day to patients who will be randomized to received ramipril
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