Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy

PHASE4CompletedINTERVENTIONAL
Enrollment

88

Participants

Timeline

Start Date

October 31, 2016

Primary Completion Date

June 30, 2018

Study Completion Date

July 31, 2018

Conditions
Vincristine Induced Peripheral Neuropathy (VIPN)
Interventions
DRUG

Injection Mecobalamin,

Injection Mecobalamin (500mcg) three times a week (day 1, 3 and 5 of vincristine chemotherapy) for 5 weeks.

DRUG

Tablet Pyridoxine hydrochloride

Tab. Pyridoxine hydrochloride (25 mg) 2 tablets thrice daily for 5 weeks

DRUG

Intravenous normal saline 1 ml

Normal saline 1 ml three times a week (day 1, 3 and 5 of vincristine chemotherapy) for 5 weeks

DRUG

Placebo pill

Placebo pill orally thrice daily for 5 weeks

Trial Locations (2)

Unknown

Bangabandhu Sheikh Mujib Medical University, Dhaka

Dhaka Medical College Hospital, Dhaka

All Listed Sponsors
lead

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

OTHER

NCT02923388 - Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy | Biotech Hunter | Biotech Hunter