Shockwave Medical Peripheral Lithoplasty System Study for PAD (Disrupt PAD III)

NACompletedINTERVENTIONAL
Enrollment

306

Participants

Timeline

Start Date

February 22, 2017

Primary Completion Date

May 12, 2020

Study Completion Date

June 2, 2022

Conditions
Peripheral Arterial Disease
Interventions
DEVICE

Shockwave Lithoplasty® Peripheral Lithoplasty System

The Shockwave Lithoplasty® System is a proprietary lithotripsy-enhanced balloon catheter that is designed to be delivered through the peripheral arterial system of the lower extremities to the site of calcified stenosis. Activating the lithotripsy within the device will generate pulsatile mechanical energy within the target treatment site, disrupt calcium within the lesion and allow subsequent dilation of a peripheral artery stenosis using low balloon pressure. The system consists of a balloon catheter with multiple integrated lithotripsy electrodes, and a generator.

DRUG

Medtronic IN.PACT (DCB)

The IN.PACT Admiral DCB is an over-the-wire (OTW) balloon catheter with a drug-coated balloon at the distal tip. The drug component, referred to as the FreePac™ drug coating, consists of the drug paclitaxel and the excipient urea. The device component physically dilates the vessel lumen by PTA, and the drug is intended to reduce the proliferative response that is associated with restenosis.

Trial Locations (54)

1023

Auckland City Hospital, Auckland

1140

Gefäßsambulanz, Vienna

8036

Medizinische Universitaet Graz, Graz

10019

Mount Sinai West, New York

10029

Icahn School of Medicine at Mount Sinai, New York

10032

Columbia University Medical Center/New York Presbyterian Hospital, New York

10713

Sankt Gertrauden-Krankenhaus, Berlin

17101

PinnacleHealth Harrisburg Hospital, Harrisburg

19010

Bryn Mawr Hospital, Bryn Mawr

19096

Lankenau Institute for Medical Research, Wynnewood

19141

Einstein Medical Center Philadelphia, Philadelphia

20010

MedStar Cardiovascular Research Network @ Medstar Washington Hospital Center, Washington D.C.

21075

Klinik für Gefäßmedizin, Hamburg

25304

Charleston Area Medical Center, Charleston

27607

NC Heart & Vascular Research, Raleigh

27610

WakeMed Health & Hospitals, Raleigh

30309

Piedmont Heart Institute, Atlanta

30501

Northeast Georgia Medical Center, Gainesville

32308

Tallahassee Research Institute, Inc., Tallahassee

37660

Wellmont CVA Heart Institute, Kingsport

37934

Tennova Healthcare - Turkey Creek Medical Center, Knoxville

38120

Baptist Medical Center, Memphis

38801

North Mississippi Medical Center, Tupelo

43214

Ohio Health Research Institute, Columbus

45468

Evangelisches Krankenhaus Mühlheim an der Ruhr, Mülheim

48075

Ascension / St. John Providence, Southfield

48145

St. Franziskus Hospital, Münster

48431

St. Joseph Mercy Oakland, Pontiac

52803

Midwest Cardiovascular Research Foundation, Davenport

53127

Leiter Sektion Angiologie, Bonn

55131

Katholisches Klinikum Mainz, Mainz

59759

Karolinen-Hospital, Arnsberg

60007

Alexian Brothers Medical Center, Elk Grove Village

60540

Advocate Health and Hospitals Corporation, Naperville

62769

Prairie Education & Research Cooperative, Springfield

64086

St. Luke's East Hospital, Lee's Summit

64111

Saint Luke's Cardiovascular Consultants, Kansas City

72211

Arkansas Heart Hospital, Little Rock

74006

St. John Clinic, Bartlesville

76646

Medizinische Klinik II, Bruchsal

77030

Baylor College of Medicine, Houston

78756

St. David's Heart and Vascular dba Austin Heart, Austin

79189

Universitäts-Herzzentrum Freiburg & Bad Krozingen, Bad Krozingen

80045

Rocky Mountain Regional VA Medical Center, Aurora

80538

UCHealth Northern Colorado, Loveland

83022

RoMed Klinikum Rosenheim, Rosenheim

94304

Stanford Hospital, Palo Alto

97213

Providence Portland Medical Center, Portland

97225

Providence Heart & Vascular Institute, Portland

06510

Yale New Haven Hospital, New Haven

02135

Steward St. Elizabeth's Medical Center, Brighton

08015

Deborah Heart and Lung Center, Browns Mills

02906

The Miriam Hospital, Providence

04103

Universitätsklinikum Leipzig AoR Leipzig, Leipzig

All Listed Sponsors
lead

Shockwave Medical, Inc.

INDUSTRY

NCT02923193 - Shockwave Medical Peripheral Lithoplasty System Study for PAD (Disrupt PAD III) | Biotech Hunter | Biotech Hunter