A Study to Examine the Effect of Omeprazole, Famotidine, and an Acidic Beverage on the Pharmacokinetics of Entinostat in Healthy Adult Subjects

PHASE1CompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

October 25, 2016

Primary Completion Date

April 19, 2017

Study Completion Date

May 8, 2017

Conditions

VolunteersHealthy VolunteersHuman VolunteersNormal Volunteers

Interventions

DRUG

entinostat

HDAC (histone deacetylase inhibitor)

DIETARY_SUPPLEMENT

Omeprazole

Proton pump inhibitor

DIETARY_SUPPLEMENT

Famotidine

Histamine-2 blocker

Trial Locations (2)

Celerion, Lincoln

Celerion, Tempe