A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Uncontrolled Severe Asthma

PHASE2CompletedINTERVENTIONAL
Enrollment

517

Participants

Timeline

Start Date

September 20, 2016

Primary Completion Date

April 5, 2019

Study Completion Date

July 26, 2019

Conditions
Asthma
Interventions
DRUG

MSTT1041A

MSTT1041A will be administered as subcutaneous injections.

DRUG

Placebo

Placebo matched with MSTT1041A.

Trial Locations (138)

16

Theramed SRL, Brasov

1000

Medical Centre Mladost Med 1 EOOD, Sofia

1051

Greenlane Clinical Centre, Auckland

1142

First MHAT; Clinic of Neurology, Sofia

1200

Cliniques Universitaires St-Luc, Brussels

1233

Fifth MHAT - Sofia EAD, Sofia

National Multiprofile Hospital Tsar Boris III, Sofia

1431

"Specialised Hospital for Active Treatment of Pulmonary Deseases Sv. Sofia, Third Clinic for Non-Sp", Sofia

Uni. Multiprofile Hosp. for Active Treatment-Aleksandrovska, Sofia

1606

Medical Center N.I. Pirogov EOOD, Sofia

1618

Alitera - Med - Medical Center EOOD, Sofia

4000

Centro Modelo de Cardiologia, San Miguel de Tucumán

4001

St Augustines Hospital; Infectoilogy, Durban

4091

Vawda Z.Fa Practice, Durban

4170

Aliwal Shoal Medical Center, eMkhomazi

5000

Medical Center Tara OOD, Veliko Tarnovo

5101

Private Practice Dr Jean Benoit Martinot, Erpent

5800

Military Medical Academy HBAT, Pleven

6000

"Medical Center Nov Rehabilitatsionen Tsentar, EOOD", Stara Zagora

6021

Medical Research Institute of New Zealand, Wellington

7002

SHATPPD Dr. Dimitar Gramatikov, Ruse Ltd., Rousse

7530

Tiervalei Trial Centre, Cape Town

7700

University of Cape Town Lung Institute; Lung Clinical Research, Cape Town

10461

Montefiore Medical Center, The Bronx

19140

Temple University Hospital, Philadelphia

20001

Hospital Santa Rosa Piura, Piura

21001

Small Business Private Enterprise Medical Centre Pulse, Vinnytsia

21236

Asthma, Allergy & Sinus Center, Baltimore

Chesapeake Clinical Research Inc - CRN, Baltimore

21502

Pneumologisches Forschungsinstitut Hohegeest, Geesthacht

23226

Commonwealth Clinical Research Specialists, Richmond

28277

American Health Research Inc., Charlotte

29303

Spartanburg Medical Research, Spartanburg

30281

Atlanta Allergy & Asth Clin PC, Stockbridge

32405

Emerald Coast Research Associates, Panama City

32789

Florida Premier Research Institute, Winter Park

35209

Alabama Allergy & Asthma, Birmingham

37208

Meharry Medical College; Clinical Trials Office, Nashville

37920

Clinical Research Solutions PC, Knoxville

38601

Ordinace pro tuberkulozu a respiracni nemoci, Strakonice

44718

Allergy & Respiratory Center, Canton

48149

Universitatsklinikum Munster, Münster

49000

Public Institution City Clinical Hospital # 6 of Dnipropetrovsk Regional Board, Dnipro

49027

Ukrainian State Institute of Medical and Social Problems of Disability, Dnipropetrovsk

54003

City Hospital #1, Mykolaiv

55131

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Medizinische Klinik, Pneumologie, Mainz

58005

Regional Municipal Institution Chernivtsi Regional Clinical Hospital, Chernivtsi

61039

SI Institute of Therapy n.a. L.T. Mala of National Academy of Medical Sciences of Ukraine, Kharkiv

63141

Midwest Clinical Research LLC, St Louis

65025

Municipal Institution Odesa Regional Clinical Hospital, Odesa

68123

The Allergy and Asthma Center, Bellevue

69104

Municipal institution; City hospital #1; Department of Therapy, Zaporizhzhia

73103

Integrity People Services Research Company, Oklahoma City

74136

Vital Prospects Clin Res Pc, Tulsa

75069

Metroplex Pulmonology & Sleep Center, McKinney

75230

Elliot J. Ginchansky, MD, PA, Dallas

76018

Regional Phthisiology and Pulmonology Center, Ivano-Frankivsk

78006

TTS Research, Boerne

78229

Allergy & Asthma Research Center, San Antonio

80033

Western States Clinical Research, Inc, Wheat Ridge

80112

IMMUNOe Research Centers, Centennial

80907

Asthma & Allergy; Associates, P.C., Colorado Springs

83301

Asthma & Allergy of Idaho, Twin Falls

84107

Allergy Associates of Utah, Murray

85710

Del Sol Research Management, Tucson

90025

CA Allergy & Asthma Med Grp; Medical Group, Inc., Los Angeles

Jonathan Corren MD, Inc., Los Angeles

90048

Office of Robert N Wolfe MD, Los Angeles

90808

Allergy & Asthma Care Center of Southern California, Long Beach

92270

Advances in Medicine, Rancho Mirage

93301

Kern Allergy Med Clinic, Inc., Bakersfield

94063

Allergy & Asthma Consultants, Redwood City

94598

Allergy and Asthma Clinical Research, Inc., Walnut Creek

95207

Bensch Research Associates, Stockton

98195

Washington Univ School of Med, Seattle

115446

I.M. Sechenov Moscow State Medical University the Ministry of Health and Social Development of RF, Moscow

117574

LLC - ABC Medicina, Moscow

150003

Clinical Emergency Hospital n.a.N.V. Soloviev, Yaroslavl

194295

Clinic Reavita LLC, Saint Petersburg

195271

SHI Ctr Occupational Pathology, Saint Petersburg

197089

St. Petersburg State Medical University n.a. I.P. Pavlov, Saint Petersburg

197706

City Hospital #40 of Resort Administrative District, Saint Petersburg

200515

Spitalul Clinic de Boli Infectioase si Pneumoftiziologie Victor Babes Craiova, Craiova

300134

Fundatia CardioPrevent, Timișoara

300310

Dr. Victor Babes Pneumology and Infectious Diseases Clinical Hospital, Timișoara

390026

Ryazan State Medical University Named after I.P.Pavlov, Ryazan

400371

Spitalul Clinic de Pneumoftiziologie Leon Daniello Cluj-Napoca, Sectia Clinica Pneumologie I, Cluj-Napoca

630008

Novosibirsk Municipal Clinical Hospital For Emergency Medicine #2, Novosibirsk

630051

City Clinical Hospital #2, Novosibirsk

634050

Siberian State Medical University, Tomsk

650099

Municipal Healthcare Institution City Clinical Hospital #3 named after M.A. Podgorbunskogo, Kemerovo

656045

City Hospital #5, Barnaul

06519

Yale University School Of Medicine, New Haven

02720

Genesis Clinical Research & Consulting, LLC, Fall River

02747

Infinity Medical Research Inc, North Dartmouth

02865

Asthma & Allergy Physicians of Rhode Island Clinical Research Institute (AAPRI CRI), Warwick

077099

Pioneer Research Solutions, Houston

C1121ABE

Fundacion Cidea, Buenos Aires

C1425BEN

INAER, Buenos Aires

M5500AYB

Fundacion Scherbovsky, Mendoza

M5500CCG

INSARES, Mendoza, Mendoza City

B1878FNR

Centro Respiratorio Quilmes, Quilmes

S2000DBS

Instituto Especialidades de la Salud Rosario, Rosario

S2000JKE

Instituto de Diagnóstico ABC; Servicio de Investigación de Patologías Alérgicas, Rosario

T4000IAR

Investigaciones en Patologias Respiratorias, San Miguel de Tucumán

B1602DQD

CEMER Centro Medico de Enfermedades Respiratorias, Vicente López

L6T 0G1

Aggarwal and Associates, Brampton

L5A 3V4

Cheema Research, Mississauga

M5T 3A9

Inspiration Research, Toronto

N8X 5A6

Anil Dhar Professional Medicine Corporation, Windsor

G8T 7A1

C.I.C. Mauricie, Trois-Rivières

377 01

MediTrial s.r.o., Jindřichův Hradec

708 00

EUC Klinika Ostrava a.s., Ostrava-Poruba

390 01

KASMED s.r.o., Tábor

415 01

Alergologie Teplice, s.r.o., Teplice

04357

POIS Leipzig Gbr, Leipzig

Lima 1

Clinica Internacional, Lima

Lima 21

Abk Reuma Srl- Medicentro, Lima

Lima 27

Clinica Ricardo Palma; THORAX, Lima

Lima 32

Instituto Peruano de Investigacion en Ciencias Medicas, Lima

Lima 41

Clinica San Borja, Lima

15-003

Centrum Medycyny Oddechowej Robert M. Mróz, Bialystok

30-033

Centrum Medyczne ALL-MED, Krakow

31-624

Malopolskie Centrum Alergologii, Krakow

31-637

Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o. sp.k., Krakow

90-153

SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi, Lodz

63-400

Specjalistyczna Poradnia Pulmonologiczna, Ostrów Wielkopolski

26-600

Przedsiebiorstwo Podmiotu Leczniczego Poradnie Specjalistyczne MAGMED, Radom

33-100

ALERGO-MED Specjalistyczna Przychodnia Lekarska Sp. z o. o, Tarnów

53-301

Ewa Pisarczyk-Bogacka Specjalistyczna Praktyka Lekarska, Wroclaw

54-239

NZOZ Lekarze Specjaliści J. Małolepszy i Partnerzy, Wroclaw

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

02091

Kyiv City Tuberculosis Hospital #1; Department of Differential Diagnosis of Lung Diseases, Kyiv

03680

SI National Institute of Phthisiology and Pulmonology n.a. F.G.Yanovskyi under NAMS of Ukraine, Kyiv

04107

Municipal Institution of Kyiv Regional Council Kyiv Regional Clinical Hospital, Kyiv

04201

Kyiv City Clinical Hospital #8, Kyiv

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02918019 - A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Uncontrolled Severe Asthma | Biotech Hunter | Biotech Hunter