7,410
Participants
Start Date
April 3, 2023
Primary Completion Date
March 31, 2029
Study Completion Date
March 31, 2029
Metformin XR
The study medication dose may be increased by a step-wise fashion up to a maximum of 4 tablets per day.
Placebo
"For patients \< 80 years of age at the time of a study visit, and with most recent eGFR 45 mL/min/1.73 m2, study medication dose may be increased in a stepwise fashion to a maximum of 4 tablets daily, corresponding to metformin XR 2000 mg or matching placebo.~For patients 80 years of age or with most recent 30 eGFR \< 45 mL/min/1.73 m2, the maximum dose of study medication is 2 tablets daily, corresponding to metformin XR 1000 mg or matching placebo"
RECRUITING
Rehabilitation R&D Service, Baltimore, MD, Baltimore
RECRUITING
Hunter Holmes McGuire VA Medical Center, Richmond, VA, Richmond
RECRUITING
Miami VA Healthcare System, Miami, FL, Miami
TERMINATED
Jesse Brown VA Medical Center, Chicago, IL, Chicago
ACTIVE_NOT_RECRUITING
Phoenix VA Health Care System, Phoenix, AZ, Phoenix
RECRUITING
VA Long Beach Healthcare System, Long Beach, CA, Long Beach
RECRUITING
Southern Arizona VA Health Care System, Tucson, AZ, Tucson
RECRUITING
Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR, Little Rock
RECRUITING
VA Loma Linda Healthcare System, Loma Linda, CA, Loma Linda
RECRUITING
VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto
RECRUITING
VA San Diego Healthcare System, San Diego, CA, San Diego
RECRUITING
VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles
RECRUITING
Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora
RECRUITING
VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven
RECRUITING
Bay Pines VA Healthcare System, Pay Pines, FL, Bay Pines
RECRUITING
North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville
RECRUITING
Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur
RECRUITING
VA Pacific Islands Health Care System, Honolulu, HI, Honolulu
RECRUITING
Edward Hines Jr. VA Hospital, Hines, IL, Hines
RECRUITING
Iowa City VA Health Care System, Iowa City, IA, Iowa City
NOT_YET_RECRUITING
Lexington VA Medical Center, Lexington, KY, Lexington
RECRUITING
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston
RECRUITING
Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis
RECRUITING
Kansas City VA Medical Center, Kansas City, MO, Kansas City
RECRUITING
Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE, Omaha
RECRUITING
New Mexico VA Health Care System, Albuquerque, NM, Albuquerque
RECRUITING
Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY, New York
RECRUITING
Durham VA Medical Center, Durham, NC, Durham
RECRUITING
Cincinnati VA Medical Center, Cincinnati, OH, Cincinnati
RECRUITING
Louis Stokes VA Medical Center, Cleveland, OH, Cleveland
RECRUITING
VA Portland Health Care System, Portland, OR, Portland
RECRUITING
Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston
RECRUITING
Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC, Columbia
RECRUITING
Memphis VA Medical Center, Memphis, TN, Memphis
RECRUITING
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas
RECRUITING
Michael E. DeBakey VA Medical Center, Houston, TX, Houston
RECRUITING
VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City
RECRUITING
Salem VA Medical Center, Salem, VA, Salem
RECRUITING
Huntington VA Medical Center, Huntington, WV, Huntington
RECRUITING
Clement J. Zablocki VA Medical Center, Milwaukee, WI, Milwaukee
VA Office of Research and Development
FED