30
Participants
Start Date
October 31, 2016
Primary Completion Date
March 31, 2020
Study Completion Date
April 30, 2020
Thioguanine (oral)
Addition of incremental doses of oral Thioguanine to oral daily 6-mercaptopurine and oral weekly methotrexate maintenance therapy of Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma. Oral 6-thioguanine is added at a starting dose of 2.5 mg/m.sq. with dose increments of 2.5 mg/m.sq. at two weeks intervals until a maximum dose of 12.5 mg/m.sq. of 6-thioguanine is given or dose-limiting toxicity occurs.
Department of Pediatrics, Rigshospitalet, Copenhagen
Rigshospitalet, Department of Hematology, Copenhagen
Odense University Hospital, Dept. Pediatric Oncology, Odense
Aarhus University Hospital Skejby, Skejby
Danish Child Cancer Foundation
OTHER
Nordic Society for Pediatric Hematology and Oncology
OTHER
Kjeld Schmiegelow
OTHER