Evaluating the Efficacy and Safety of a Sequencing Schedule of Cobimetinib Plus Vemurafenib Followed by Immunotherapy With an Anti- PD-L1 Antibody in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma

PHASE2CompletedINTERVENTIONAL
Enrollment

186

Participants

Timeline

Start Date

November 30, 2016

Primary Completion Date

March 31, 2024

Study Completion Date

March 31, 2024

Conditions
Malignant Melanoma
Interventions
DRUG

Vemurafenib

960 mg vemurafenib BID until progression or unacceptable toxicity develops

DRUG

Cobimetinib

60 mg cobimetinib QD, 21/7 until progression or unacceptable toxicity develops

DRUG

Atezolizumab

1200 mg atezolizumab administered intravenously on day 1 of each 21 day-cycle. Will be given until progression or unacceptable toxicity develops

Trial Locations (27)

10117

Charité-Universitätsmedizin Berlin, Berlin

11000

Military Medical Academy, Belgrade

11527

"LAIKO" General Hospital of Athens, Athens

13885

Hôpital de la Timone, Marseille

21614

Elbe Kliniken Stade - Buxtehude, Buxtehude

23538

Universitätsklinikum Schleswig-Holstein, Lübeck

24105

Universitäts-Hautklinik Kiel, Kiel

30625

Medizinische Hochschule Hannover, Hanover

32429

Johannes Wesling Klinikum Minden, Minden

44093

CHU de Nantes, Nantes

45122

University Hospital Essen, Department of Dermatology, Skin Cancer Center, Essen

50937

Universitätsklinikum Köln, Cologne

55131

Universitätsklinikum Mainz, Mainz

59000

Hospital Claude Huriez, Lille

66421

Universitätsklinikum des Saarlandes, Homburg/Saar

67063

Gesellschaft für Klinische Forschung Ludwigshafen mbH, Ludwigshafen

68167

University Hospital Mannheim, Clinic for Dermatology, Mannheim

69120

National Centre for Tumour Diseases (NCT), Heidelberg

69310

Centre Hospitalier Lyon Sud, Pierre-Bénite

72076

Universitätsklinikum Tübingen, Tübingen

74078

SLK-Kliniken Heilbronn GmbH, Heilbronn

80337

Klinikum der Universität München, München

92104

Hôpital Ambroise-Paré, Boulogne-Billancourt

97080

Uniklinikum Würzburg, Würzburg

99089

HELIOS Klinikum Erfurt, Erfurt

01307

Universitätsklinik Dresden, Dresden

04103

Universitätsklinikum Leipzig, Leipzig

All Listed Sponsors
lead

University Hospital, Essen

OTHER

NCT02902029 - Evaluating the Efficacy and Safety of a Sequencing Schedule of Cobimetinib Plus Vemurafenib Followed by Immunotherapy With an Anti- PD-L1 Antibody in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma | Biotech Hunter | Biotech Hunter