Ectopic Adipose Tissue, Exercise Training and IL-6

Three months of supervised training. Interval training, 3 sessions weekly of 45 min. During intervals the intensity will be minimum 70 % of VO2 max

Three months of supervised resistance training. Subjects will perform 3 weekly sessions of 45 min. The intensity will be kept at minimum 60% of 1RM.

Control to exercise

Tocilizumab infusion will be administered monthly (8 mg/kg body weight i.v., maximun 800 mg). Each subject will receive 3 infusions during the study period.

Saline infusion will be administered monthly (same volume as Tocilizumab). Each subject will receive 3 infusions during the study period.