NCT02893553 - The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

December 31, 2016

Primary Completion Date

December 31, 2021

Study Completion Date

December 31, 2021

Conditions

Spinal Cord InjuryAutonomic DysreflexiaBaroreceptor IntegritySympathetic IntegrityVagal IntegrityAutonomic IntegrityHypotensiveCognitive FunctionCerebral Blood FlowBlood Pressure

Interventions

DRUG

Midodrine Hydrochloride

study 1 will be single blind. study 2 will be blinded randomized-control trial.

DRUG

Pyridostigmine Bromide

study 1 will be single blind. study 2 will be blinded randomized-control trial.

DRUG

Mirabegron

study 1 will be single blind. study 2 will be blinded randomized-control trial.

OTHER

Placebo

placebo will only be used for study arm 2, the randomized blinded phase.

Trial Locations (2)

10468

James J Peters VAMC, The Bronx

07052

Kessler Foundation Research Center, West Orange