A Randomised Trial of Chemotherapy Plus Surgery for Recurrent Non-Small Cell Lung Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

500

Participants

Timeline

Start Date

January 31, 2008

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Recurrent Non-small Cell Lung Cancer
Interventions
DRUG

Cisplatin

Procedure: Preoperative chemotherapy using Cisplatin (60mg) as single agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.

DRUG

Carboplatin

Procedure: Preoperative chemotherapy using Carboplatin (400mg) as single agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.

DRUG

Docetaxel

Procedure: Preoperative chemotherapy using Docetaxel (120mg) as single agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.

DRUG

Gemcitabine/Carboplatin

Procedure: Preoperative chemotherapy using Gemcitabine (200mg) and Carboplatin (400mg) as combinational therapy agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.

DRUG

Gemcitabine/Cisplatin

Procedure: Preoperative chemotherapy using Gemcitabine (200mg) and Cisplatin (60mg) as combinational therapy agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.

DRUG

Docetaxel/Oxaliplatin

Procedure: Preoperative chemotherapy using Docetaxel (120mg) and Oxaliplatin (200mg) as combinational therapy agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.

DRUG

Docetaxel/Carboplatin

Procedure: Preoperative chemotherapy using Docetaxel (120mg) and Carboplatin (400mg) as combinational therapy agent was performed 30 days before surgery through intravenous (IV) administration. IV administration once every 7 days, totally 4 cycles. There is a 2-day interval between the last dose and surgery.

DRUG

Placebo

Regular placebo in replacement of agent-specific chemotherapy was supplied to these patients.

Trial Locations (3)

130033

RECRUITING

China-Japan Union Hospital, Jilin University, Changchun

200072

RECRUITING

Shanghai 10th People's Hospital, Shanghai

200433

RECRUITING

Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai

All Listed Sponsors
collaborator

Shanghai 10th People's Hospital

OTHER

collaborator

Jilin University

OTHER

collaborator

Jiangxi Provincial Cancer Hospital

OTHER

collaborator

Shanghai Tongji Hospital, Tongji University School of Medicine

OTHER

lead

Shanghai Jiao Tong University School of Medicine

OTHER