Immunologic Profile of Chronically Photodamaged Skin

0.1 milliliter (mL) injection into superficial dermis making small bleb at Baseline Visit.

0.01 milliliter (mL) of histamine phosphate injected into the superficial dermis making a small bleb at Baseline Visit.

Pea sized amount of 5% cream to be applied to designated areas once daily for 4 days, beginning at Baseline Visit.

At Baseline Visit, adhesive tape firmly applied to designated area for 2 seconds, then removed. Procedure repeated between 20 and 50 times until skin is slightly red and tacky.