Systemic Oxaliplatin or Intra-arterial Chemotherapy Combined With LV5FU2 +/- Irinotecan and an Target Therapy in First Line Treatment of Metastatic Colorectal Cancer Restricted to the Liver

PHASE3RecruitingINTERVENTIONAL
Enrollment

348

Participants

Timeline

Start Date

December 31, 2016

Primary Completion Date

September 30, 2028

Study Completion Date

September 30, 2028

Conditions
Colorectal Neoplasms
Interventions
DRUG

Oxaliplatin intravenous

85 mg/m² in intravenous. 1 cycle each 15 days

DRUG

5 FU bolus

5 fluorouracil : 400 mg/m² in bolus of 10 minutes (intravenous) following by 2400 mg/m² during 46 hours in intravenous

DRUG

Folinic acid

400 mg/m² in intravenous

DRUG

Oxaliplatin intra-arteriel

85 mg/m² in intra-arterial. 1 cycle each 15 days

DRUG

Panitumumab

Only for patient RAS wild: 6 mg/Kg at each cycle in intravenous

DRUG

Bevacizumab

5 mg/kg at each cycle in intravenous

DRUG

5 FU continuous

2400 mg/m² intravenously over 46 hours

DRUG

Irinotecan

150 mg/m² intravenous

Trial Locations (49)

Unknown

RECRUITING

Hôpital Erasme, Brussels

RECRUITING

Chu Hotel Dieu, Angers

RECRUITING

Institut de Cancérologie de l'Ouest, Angers

RECRUITING

Hôpital Privé d'Antony, Antony

NOT_YET_RECRUITING

CH Henri Duffaut, Avignon

RECRUITING

Institut du cancer Avignon Provence, Avignon

RECRUITING

Ch Cote Basque, Bayonne

RECRUITING

Clinique Belharra, Bayonne

NOT_YET_RECRUITING

Centre Hospitalier, Beauvais

RECRUITING

Institut Bergonié, Bordeaux

RECRUITING

Polyclinique Bordeaux Nord, Bordeaux

RECRUITING

Infirmerie Protestante de Lyon, Caluire-et-Cuire

NOT_YET_RECRUITING

CH Loire Vendée Océan, Challans

RECRUITING

Centre Hospitalier Sud Francilien, Corbeil-Essonnes

NOT_YET_RECRUITING

Chu Le Bocage, Dijon

RECRUITING

Chd Vendee, La Roche-sur-Yon

RECRUITING

Groupe Hospitalier de la Rochelle Re-Aunis, La Rochelle

NOT_YET_RECRUITING

Ch de Bicetre, Le Kremlin-Bicêtre

NOT_YET_RECRUITING

GH Nord Essone, Longjumeau

RECRUITING

Hôpital du Scorff, Lorient

RECRUITING

Centre Léon Bérard, Lyon

RECRUITING

Hôpital de la Croix Rousse, Lyon

RECRUITING

Hôpital Européen, Marseille

RECRUITING

Hôpital Saint-Joseph, Marseille

NOT_YET_RECRUITING

Institut Paoli Calmettes, Marseille

RECRUITING

Chu Hotel Dieu, Nantes

NOT_YET_RECRUITING

CHR La Source, Orléans

NOT_YET_RECRUITING

Hôpital Cochin, Paris

RECRUITING

Hôpital Saint Joseph, Paris

RECRUITING

Hôpital Saint Louis, Paris

RECRUITING

Paris Hôpital Européen Georges Pompidou, Paris

RECRUITING

Centre Hospitalier, Pau

RECRUITING

Centre Hospitalier Saint Jean, Perpignan

RECRUITING

CHU Haut Lévêque, Pessac

RECRUITING

CHU La Milétrie, Poitiers

RECRUITING

Centre Eugène Marquis, Rennes

NOT_YET_RECRUITING

Clinique Pasteur, Ris-Orangis

NOT_YET_RECRUITING

CROME, Ris-Orangis

RECRUITING

CHU Charles Nicolle, Rouen

RECRUITING

CHP, Saint-Grégoire

RECRUITING

Institut de cancérologie de l'Ouest, Saint-Herblain

RECRUITING

CHU Saint-Etienne, Saint-Priest-en-Jarez

RECRUITING

Hôpital FOCH, Suresnes

NOT_YET_RECRUITING

Maison de Santé Protestante de Bordeaux Bagatelle, Talence

RECRUITING

Hia Sainte Anne, Toulon

RECRUITING

Chu Toulouse Rangueil, Toulouse

NOT_YET_RECRUITING

Clinique Pasteur, Toulouse

NOT_YET_RECRUITING

Hôpital Paul Brousse, Villejuif

RECRUITING

Institut Gustave Roussy, Villejuif

All Listed Sponsors
lead

Federation Francophone de Cancerologie Digestive

OTHER