Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction

PHASE3CompletedINTERVENTIONAL
Enrollment

592

Participants

Timeline

Start Date

November 23, 2016

Primary Completion Date

May 16, 2022

Study Completion Date

May 16, 2022

Conditions
Chronic Heart Failure (CHF)
Interventions
DRUG

LCZ696

LCZ696 50, 100, and 200 mg tablets taken orally twice daily with matching placebo for valsartan

DRUG

Valsartan

Valsartan 40, 80, and 160 mg tablets taken orally twice daily with matching placebo for LCZ696

DRUG

Placebo of LCZ696

Placebo to match LCZ696 50 mg, 100 mg, and 200 mg tablets

DRUG

Placebo of Valsartan

Placebo to match valsartan 40 mg, 80 mg, and 160 mg tablets

Trial Locations (135)

1407

Novartis Investigative Site, CABA

Novartis Investigative Site, Sofia

1431

Novartis Investigative Site, Sofia

3220

Novartis Investigative Site, Geelong

4031

Novartis Investigative Site, Basel

4032

Novartis Investigative Site, Chemside

4064

Novartis Investigative Site, Milton

5042

Novartis Investigative Site, Bedford Park

9300

Novartis Investigative Site, Aalst

10000

Novartis Investigative Site, Zagreb

10002

Novartis Investigative Site, Taipei

10367

Novartis Investigative Site, Berlin

11217

Novartis Investigative Site, Taipei

13125

Novartis Investigative Site, Buch

13353

Novartis Investigative Site, Berlin

13620

Novartis Investigative Site, Seongnam-si

14215

Novartis Investigative Site, Buffalo

20089

Novartis Investigative Site, Rozzano

21229

Novartis Investigative Site, Baltimore

24127

Novartis Investigative Site, Bergamo

26426

Novartis Investigative Site, Wŏnju

26480

Novartis Investigative Site, Meselik

28034

Novartis Investigative Site, Madrid

28040

Novartis Investigative Site, Madrid

28041

Novartis Investigative Site, Madrid

28054

Novartis Investigative Site, Gastonia

28702

Novartis Investigative Site, San Sebastián de los Reyes

29485

Novartis Investigative Site, Summerville

29707

Novartis Investigative Site, Fort Mill

29732

Novartis Investigative Site, Rock Hill

31271

Novartis Investigative Site, Krakow

32050

Novartis Investigative Site, Jacksonville Beach

32127

Novartis Investigative Site, Port Orange

32132

Novartis Investigative Site, Edgewater

33030

Novartis Investigative Site, Homestead

33133

Novartis Investigative Site, Miami

33144

Novartis Investigative Site, Miami

33176

Novartis Investigative Site, Miami

33312

Novartis Investigative Site, Hollywood

33604

Novartis Investigative Site, Bielefeld

33612

Novartis Investigative Site, Tampa

33756

Novartis Investigative Site, Clearwater

34102

Novartis Investigative Site, Naples

34452

Novartis Investigative Site, Inverness

36420

Novartis Investigative Site, Andalusia

41100

Novartis Investigative Site, Modena

42109

Novartis Investigative Site, Wuppertal

44100

Novartis Investigative Site, Cona

45219

Novartis Investigative Site, Cincinnati

46010

Novartis Investigative Site, Valencia

46026

Novartis Investigative Site, Valencia

48601

Novartis Investigative Site, Saginaw

50009

Novartis Investigative Site, Zaragoza

50134

Novartis Investigative Site, Florence

50937

Novartis Investigative Site, Cologne

51000

Novartis Investigative Site, Rijeka

51065

Novartis Investigative Site, Cologne

54634

Novartis Investigative Site, Bitburg

56124

Novartis Investigative Site, Pisa

58140

Novartis Investigative Site, Sivas

59208

Novartis Investigative Site, Tourcoing

60128

Novartis Investigative Site, Ancona

60148

Novartis Investigative Site, Lombard

60594

Novartis Investigative Site, Frankfurt

62701

Novartis Investigative Site, Springfield

63110

Novartis Investigative Site, St Louis

66606

Novartis Investigative Site, Topeka

70403

Novartis Investigative Site, Tainan City

70535

Novartis Investigative Site, Eunice

75013

Novartis Investigative Site, Paris

75226

Novartis Investigative Site, Dallas

75235

Novartis Investigative Site, Dallas

75904

Novartis Investigative Site, Lufkin

77030

Novartis Investigative Site, Houston

78229

Novartis Investigative Site, San Antonio

78629

Novartis Investigative Site, Gonzales

85004

Novartis Investigative Site, Phoenix

85206

Novartis Investigative Site, Mesa

85306

Novartis Investigative Site, Glendale

85375

Novartis Investigative Site, Sun City West

85723

Novartis Investigative Site, Tucson

86077

Novartis Investigative Site, Pozzilli

89077

Novartis Investigative Site, Ulm

89502

Novartis Investigative Site, Reno

90211

Novartis Investigative Site, Beverly Hills

90503

Novartis Investigative Site, Torrance

90806

Novartis Investigative Site, Long Beach

92357

Novartis Investigative Site, Loma Linda

92663

Novartis Investigative Site, Newport Beach

92704

Novartis Investigative Site, Santa Ana

92705

Novartis Investigative Site, Santa Ana

93053

Novartis Investigative Site, Regensburg

93720

Novartis Investigative Site, Fresno

97045

Novartis Investigative Site, Oregon City

97080

Novartis Investigative Site, Würzburg

97477

Novartis Investigative Site, Springfield

98405

Novartis Investigative Site, Tacoma

127644

Novartis Investigative Site, Moscow

196601

Novartis Investigative Site, Saint Petersburg

197022

Novartis Investigative Site, Saint Petersburg

199106

Novartis Investigative Site, Saint Petersburg

410012

Novartis Investigative Site, Saratov

06810

Novartis Investigative Site, Danbury

59901 3158

Novartis Investigative Site, Kalispell

08318

Novartis Investigative Site, Elmer

C1405BCK

Novartis Investigative Site, Buenos Aires

C1119ACN

Novartis Investigative Site, Ciudad Autonoma de Bs As

B1704ETD

Novartis Investigative Site, Ramos Mejía

C1179AAB

Novartis Investigative Site, CABA

L8L 2X2

Novartis Investigative Site, Hamilton

J4V 2G8

Novartis Investigative Site, Greenfield Park

01099

Novartis Investigative Site, Dresden

06846

Novartis Investigative Site, Dessau

01277

Novartis Investigative Site, Dresden

04910

Novartis Investigative Site, Elsterwerda

LT 50161

Novartis Investigative Site, Kaunas

LT-08661

Novartis Investigative Site, Vilnius

5223 GZ

Novartis Investigative Site, 's-Hertogenbosch

1081 HV

Novartis Investigative Site, Amsterdam

33-100

Novartis Investigative Site, Tarnów

15 276

Novartis Investigative Site, Bialystok

40-645

Novartis Investigative Site, Katowice

31 202

Novartis Investigative Site, Krakow

02-097

Novartis Investigative Site, Warsaw

90 549

Novartis Investigative Site, Lodz

03080

Novartis Investigative Site, Seoul

BS26 2BJ

Novartis Investigative Site, Axbridge

CF5 4AD

Novartis Investigative Site, Cardiff

B16 8QQ

Novartis Investigative Site, Birmingham

BH7 7DW

Novartis Investigative Site, Bournemouth

HU16 5JQ

Novartis Investigative Site, East Yorkshire

HA1 3UJ

Novartis Investigative Site, Harrow

L9 7AL

Novartis Investigative Site, Liverpool

NP20 2UB

Novartis Investigative Site, Newport

SG1 4AB

Novartis Investigative Site, Stevenage

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY