150
Participants
Start Date
November 30, 2016
Primary Completion Date
October 1, 2023
Study Completion Date
October 1, 2026
Metformin
Initial: 500 mg once daily; dosage may be increased by 500 mg weekly; maximum dose: 2,000 mg once daily
Gliclazide
"There is no fixed-dosage regimen for the management of diabetes mellitus with gliclazide. Dose will be individualized based on frequent determinations of blood glucose during dose titration and throughout maintenance. The 30 mg modified-release tablet equals the 80 mg immediate-release tablet.~Immediate-release tablet: Initial: 80 mg twice daily; titrate based on blood glucose levels. Usual dosage range: 80 to 320 mg/day (maximum dose: 320 mg/day); dosage of ≥160 mg should be divided into 2 equal parts for twice-daily administration.~Modified-release tablet: Initial: 30 mg once daily; titrate in 30 mg increments every 2 weeks based on blood glucose levels. Maximum dose: 120 mg once daily"
Sitagliptin
Oral: 100 mg once daily
Liraglutide
SubQ: Initial: 0.6 mg once daily for 1 week; then increase to 1.2 mg once daily; may increase further to 1.8 mg once daily if optimal glycemic response not achieved with 1.2 mg daily.
Pioglitazone
"Oral, Monotherapy or combination therapy: 15-30 mg once daily~Patients with heart failure (NYHA Class I or II): Monotherapy or combination therapy: 15 mg once daily"
Dapagliflozin
5mg once daily increasing to 10mg once daily as required
human insulin
insulin dosage and administration according to physician
Hamad Medical Corporation, Doha
Collaborators (1)
Hamad Medical Corporation
INDUSTRY
Sidra Medicine
OTHER
University of Hull
OTHER
Weill Cornell Medical College in Qatar
OTHER