Tranexamic Acid in Revision Total Joint Arthroplasty

PHASE4CompletedINTERVENTIONAL
Enrollment

175

Participants

Timeline

Start Date

April 30, 2016

Primary Completion Date

August 1, 2019

Study Completion Date

August 1, 2019

Conditions
Revision Total Knee ArthroplastyRevision Total Hip ArthroplastyAcute Blood Loss Anemia
Interventions
PROCEDURE

Revision Total Knee Arthroplasty (TKA)

Femoral component exchange, tibial component exchange, both component exchange, explant of both components and placement of antibiotic cement spacer, or a second stage re-implantation procedure. Given the variability in blood loss between types of revision TKA, randomization will be done to ensure equivalent numbers of each type of revision TKA between the treatment groups.

PROCEDURE

Revision Total Hip Arthroplasty (THA)

Femoral component exchange, acetabulum component exchange, both component exchange, explant of both components and placement of antibiotic cement spacer, or a second stage re-implantation procedure. Given the variability in blood loss between types of revision THA, randomization will be done to ensure equivalent numbers of each type of revision THA between the treatment groups.

Trial Locations (3)

55905

Mayo Clinic, Rochester

60612

Rush University Medical Center, Chicago

Unknown

New York University Medical Center, New York

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Mayo Clinic

OTHER

lead

Rush University Medical Center

OTHER