ACTolog in Patients With Solid Cancers

PHASE1CompletedINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

June 30, 2017

Primary Completion Date

September 22, 2021

Study Completion Date

September 22, 2021

Conditions
CancerSolid Tumor
Interventions
DRUG

Fludarabine

Fludarabine infusion

DRUG

Cyclophosphamide

Cyclophosphamide infusion

BIOLOGICAL

IMA101 product

i.v. infusion of IMA101 product(s).

BIOLOGICAL

Recombinant human interleukin-2

Low dose IL-2 Infusion for two weeks

DIAGNOSTIC_TEST

IMADetect

IMADetect is a laboratory test that is part of screening used to determine the mRNA expression of ACTolog target source genes in tumor biopsies from solid tumors. IMADetect is intended for investigational use only.

DRUG

Atezolizumab

Atezolizumab infusion will be given no earlier than 3 weeks post IMA101 infusion and after hematologic recovery is achieved, thereafter every 3 weeks until 1 year after IMA101 infusion.

Trial Locations (1)

77030

University of Texas MD Anderson Cancer Center, Houston

All Listed Sponsors
collaborator

M.D. Anderson Cancer Center

OTHER

lead

Immatics US, Inc.

INDUSTRY

NCT02876510 - ACTolog in Patients With Solid Cancers | Biotech Hunter | Biotech Hunter