HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

250

Participants

Timeline

Start Date

September 30, 2015

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2030

Conditions
MedulloblastomaCentral Nervous System Embryonal Tumors
Interventions
DRUG

Induction

vincristine, cisplatin, cyclophosphamide, etoposide, high-dose methotrexate

DRUG

Single Cycle Intensive Chemotherapy

Carboplatin, thiotepa, etoposide

DRUG

Tandem 3 Cycle Intensive Chemotherapy

Carboplatin, thiotepa

Trial Locations (62)

10016

NYU Langone Medical Center, New York

10032

Columbia Presbyterian Children's Hospital, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10532

New York Medical College, Hawthorne

11549

Northwell Health, Hempstead

13210

Upstate Golisano Children's Hospital/ SUNY Upstate Medical University, Syracuse

17033

Penn State Hershey Children's Hospital, Hershey

19104

Children's Hospital of Philadelphia, Philadelphia

19803

Nemours Center for Cancer and Blood Disorders, Wilmington

Nemours Center for Cancer and Blood Disorders, Jacksonville

20010

Children's National Medical Center, Washington D.C.

21287

John's Hopkins University School of Medicine, Baltimore

23219

Virginia Commonwealth University, Richmond

27710

Duke University Medical Center, Durham

28204

Carolina's HealthCare System/Levine Cancer Institute, Charlotte

29425

Medical University of South Carolina, Charleston

30342

Children's Healthcare of Atlanta, Atlanta

32608

Shands Children's Hospital/ University of FL, Gainesville

32806

Orlando Health, Orlando

33155

Nicklaus Children's Hospital, Miami

33701

John's Hopkins All Children's Hospital, St. Petersburg

35233

Children's of Alabama, Birmingham

37232

Vanderbilt-Ingram Cancer Center, Nashville

40202

University of Louisville School of Medicine, Louisville

43205

Nationwide Children's Hospital, Columbus

44106

Rainbow Babies & Children's Hospital, Cleveland

44195

Cleveland Clinic, Cleveland

44308

Akron Children's Hospital, Akron

45404

Dayton Children's Hospital, Dayton

46202

Riley Children's Hospital/University of Indiana, Indianapolis

48109

University of Michigan, Ann Arbor

48201

Central Michigan University, Detroit

49503

Helen DeVos Children's Hospital, Grand Rapids

52242

University of Iowa Hospital and Clinics, Iowa City

53792

American Family Children's Hospital/University of Wisconsin, Madison

55404

Children's Hospital of Minnesota, Minneapolis

55454

Masonic Children's Hospital/University of Minnesota, Minneapolis

55905

Mayo Clinic, Rochester

58226

Medical College of Wisconsin, Milwaukee

63110

Washington University School of Medicine, St Louis

72202

Arkansas Children's Hospital, Little Rock

77030

MD Anderson Cancer Center, Houston

80045

Children's Hospital Colorado, Aurora

84113

Primary Children's Hospital, Salt Lake City

85016

Phoenix Children's Hospital, Phoenix

89135

Children's Specialty Care of Nevada, Las Vegas

90027

Children's Hospital Los Angeles, Los Angeles

90095

Mattel Children's Hospital (UCLA), Los Angeles

90806

Memorial Care Health Services, Long Beach

91868

Children's Hospital Orange County, Orange

92350

Loma Linda University Medical Center, Loma Linda

94609

UCSF Oakland Benioff, Oakland

02215

Dana Farber Cancer Institute, Boston

07601

Joseph Sanzari Children's Hospital/ Hackensack University, Hackensack

07960

Morristown Medical Center, Atlantic Health System, Morristown

V6H 3V4

B.C. Children's Hospital, Vancouver

Unknown

Alberta Children's Hospital, Calgary

Stollery Children's Hospital, Edmonton

Hamilton Health/McMasters Children's Hospital, Hamilton, Canada, Hamilton

The Hospital of Sick Children, Toronto

Starship Children's Hospital, Auckland

Christchurch Children's Hospital, Christchurch

All Listed Sponsors
collaborator

Children's of Alabama

OTHER

lead

Parth Patel

OTHER

NCT02875314 - HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors | Biotech Hunter | Biotech Hunter