A Dose Escalation Trial of SBRT After Induction Chemotherapy for Locally Advanced Pancreatic Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

14

Participants

Timeline

Start Date

November 17, 2016

Primary Completion Date

June 7, 2019

Study Completion Date

November 28, 2022

Conditions
Pancreatic Cancer
Interventions
DRUG

FOLFIRINOX or gemcitabine/abraxane

Patients will have received induction chemotherapy for 3+ months with either FOLFIRINOX or gemcitabine/abraxane with at least stable disease.

RADIATION

SBRT

After completion of induction chemotherapy, stereotactic body radiation therapy (SBRT) will be administered in 3 fractions, every other day, on an outpatient basis. Dose escalation will start with dose level 1 (9 Gy x 3 fractions) and increase by 1 Gy per fraction at each dose level, dose level 2 will be 10 Gy x 3 fractions and dose level 3 will be 11 Gy x 3 fractions.

Trial Locations (1)

80045

University of Colorado, Aurora

All Listed Sponsors
lead

University of Colorado, Denver

OTHER

NCT02873598 - A Dose Escalation Trial of SBRT After Induction Chemotherapy for Locally Advanced Pancreatic Cancer | Biotech Hunter | Biotech Hunter