Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation

NAActive, not recruitingINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

December 31, 2016

Primary Completion Date

June 5, 2024

Study Completion Date

November 30, 2034

Conditions
Breast Cancer
Interventions
PROCEDURE

Controlled ovarian hyperstimulation (COH)

"After information and consent, patients are addressed to a reproductive medicine center.~The COH will be performed according to a standardized protocol between surgery and the start of adjuvant chemotherapy. Follicular growth will be achieved with an antagonist protocol and by using high dose recombinant FSH (r-FSH). The triggering of the final follicular and oocyte maturation will be obtained by a GnRH (Gonadotropin Releasing Hormone) agonist injection in order to minimize the risk of ovarian hyper-stimulation."

PROCEDURE

Oocyte/embryo freezing

Egg or embryo freezing will be performed according to a standardized protocol: slow-freezing process for embryo; vitrification technique for oocytes. Cryopreserved oocytes and embryos will be stored in the biological bank of each reproductive medicine center (min. 10 years).

Trial Locations (28)

13005

CHU La Conception, Marseille

13273

Institut Paoli Calmette, Marseille

14033

CHU de Caen, Caen

14076

Centre François Baclesse, Caen

21079

Centre Georges François LECLERC, Dijon

CHU de Dijon, Dijon

31059

Oncopole-CHU Toulouse, Toulouse

33076

Centre Aliénor d'Aquitaine, Hôpital Pellegrin, Bordeaux

34295

CHRU Montpellier, Montpellier

34298

ICM - Val d'Aurelle, Montpellier

54000

CHRU de Nancy, Nancy

54519

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

59020

Centre Oscar Lambret, Lille

59037

CHRU Hôpital Jeanne de Flandres, Lille

67091

Hôpital Universitaire de Strasbourg, Strasbourg

69229

CHU Lyon, Lyon

69373

Centre Léon Bérard, Lyon

75005

Institut Curie, Paris

75014

Hôpital Cochin, Paris

75020

Hôpital TENON, Paris

76031

CHU Rouen, Rouen

76038

Centre Henri Becquerel, Rouen

87042

CHU Limoges, Limoges

92140

Hôpital Antoine Béclère, Clamart

92210

Institut Curie, Saint-Cloud

93140

Hôpital Jean Verdier, Bondy

94805

Institut Gustave Roussy, Villejuif

97410

CHU REUNION site SUD, La Réunion

All Listed Sponsors
collaborator

University Hospital, Lille

OTHER

collaborator

National Cancer Institute, France

OTHER_GOV

collaborator

University Hospital, Montpellier

OTHER

lead

Centre Oscar Lambret

OTHER

NCT02871167 - Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation | Biotech Hunter | Biotech Hunter