Blood Flow Restriction Exercise Study

NACompletedINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

December 12, 2016

Primary Completion Date

August 1, 2018

Study Completion Date

August 1, 2018

Conditions
Osteoarthritis, Knee
Interventions
DEVICE

Strength testing

Test the strength of subject's lower extremity muscles on the dynamometer system

BEHAVIORAL

Short Physical Performance Battery (SPPB)

The SPPB is a timed short distance walk, repeated chair stands, and balance test that measures lower extremity function.

BEHAVIORAL

Six-minute walk (SMW)

Subjects walk back and forth along a 100-ft hallway for six minutes after instructions to complete as many laps as possible.

BEHAVIORAL

Numerical pain scale

Measure pain using an 11-point numerical pain scale.

BEHAVIORAL

Self-assessed function

Using the Late Life Function and Disability Instrument.

PROCEDURE

Muscle biopsies

During the course of the surgery two small muscle biopsies from the quadriceps muscle of the operative leg will be collected.

DEVICE

Determination of 1 Repetition Maximum (1-RM)

Following the warm-up, subjects will attempt to complete one repetition of the leg press exercise at progressively greater resistance until a full repetition can no longer be performed. The weight of the last complete unassisted repetition will be recorded as the 1-RM.

DEVICE

Blood flow restriction exercise

Perform lower-extremity exercises (leg press, leg extension, leg curl, and calf extension) at an intensity of 30% of 1-RM with external compression applied to the proximal thigh of each leg.

BEHAVIORAL

Borg CR10 scale

Following each exercise session, participants will provide a rating of perceived exertion (RPE) for the session according to the Borg CR10 scale.

Trial Locations (1)

32610-3003

United States, Florida UF Health, Gainesville

All Listed Sponsors
collaborator

University of Florida Clinical and Translational Science Institute (CTSI)

UNKNOWN

lead

University of Florida

OTHER

NCT02868021 - Blood Flow Restriction Exercise Study | Biotech Hunter | Biotech Hunter