12
Participants
Start Date
December 12, 2016
Primary Completion Date
August 1, 2018
Study Completion Date
August 1, 2018
Strength testing
Test the strength of subject's lower extremity muscles on the dynamometer system
Short Physical Performance Battery (SPPB)
The SPPB is a timed short distance walk, repeated chair stands, and balance test that measures lower extremity function.
Six-minute walk (SMW)
Subjects walk back and forth along a 100-ft hallway for six minutes after instructions to complete as many laps as possible.
Numerical pain scale
Measure pain using an 11-point numerical pain scale.
Self-assessed function
Using the Late Life Function and Disability Instrument.
Muscle biopsies
During the course of the surgery two small muscle biopsies from the quadriceps muscle of the operative leg will be collected.
Determination of 1 Repetition Maximum (1-RM)
Following the warm-up, subjects will attempt to complete one repetition of the leg press exercise at progressively greater resistance until a full repetition can no longer be performed. The weight of the last complete unassisted repetition will be recorded as the 1-RM.
Blood flow restriction exercise
Perform lower-extremity exercises (leg press, leg extension, leg curl, and calf extension) at an intensity of 30% of 1-RM with external compression applied to the proximal thigh of each leg.
Borg CR10 scale
Following each exercise session, participants will provide a rating of perceived exertion (RPE) for the session according to the Borg CR10 scale.
United States, Florida UF Health, Gainesville
University of Florida Clinical and Translational Science Institute (CTSI)
UNKNOWN
University of Florida
OTHER