Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

109

Participants

Timeline

Start Date

May 18, 2017

Primary Completion Date

June 30, 2021

Study Completion Date

June 27, 2026

Conditions
Adrenal Cortical CarcinomaAlveolar Soft Part SarcomaCentral Nervous System NeoplasmChildhood Clear Cell Sarcoma of Soft TissueClear Cell Sarcoma of Soft TissueEwing SarcomaHepatoblastomaHepatocellular CarcinomaOsteosarcomaRecurrent Adrenal Cortical CarcinomaRecurrent Alveolar Soft Part SarcomaRecurrent Clear Cell Sarcoma of Soft TissueRecurrent Ewing SarcomaRecurrent HepatoblastomaRecurrent Hepatocellular CarcinomaRecurrent Kidney Wilms TumorRecurrent Malignant Solid NeoplasmRecurrent OsteosarcomaRecurrent Primary Malignant Central Nervous System NeoplasmRecurrent Renal Cell CarcinomaRecurrent RhabdomyosarcomaRecurrent Soft Tissue SarcomaRecurrent Thyroid Gland Medullary CarcinomaRefractory Adrenal Cortical CarcinomaRefractory Alveolar Soft Part SarcomaRefractory Clear Cell Sarcoma of Soft TissueRefractory Ewing SarcomaRefractory HepatoblastomaRefractory Hepatocellular CarcinomaRefractory Malignant Solid NeoplasmRefractory OsteosarcomaRefractory Primary Central Nervous System NeoplasmRefractory Primary Malignant Central Nervous System NeoplasmRefractory Renal Cell CarcinomaRefractory RhabdomyosarcomaRefractory Soft Tissue SarcomaRefractory Thyroid Gland Medullary CarcinomaRefractory Wilms TumorRenal Cell CarcinomaRhabdomyosarcomaSoft Tissue SarcomaSolid NeoplasmThyroid Gland Medullary CarcinomaWilms Tumor
Interventions
DRUG

Cabozantinib

Given PO

DRUG

Cabozantinib S-malate

"Given PO~Note: Capsule formulation (Cometriq) not used in this trial."

OTHER

Pharmacological Study

Correlative studies

Trial Locations (142)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

11040

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park

11501

NYU Langone Hospital - Long Island, Mineola

13210

State University of New York Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

15224

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

19104

Children's Hospital of Philadelphia, Philadelphia

19803

Alfred I duPont Hospital for Children, Wilmington

20002

Kaiser Permanente-Capitol Hill Medical Center, Washington D.C.

20007

MedStar Georgetown University Hospital, Washington D.C.

20010

Children's National Medical Center, Washington D.C.

20892

National Institutes of Health Clinical Center, Bethesda

21215

Sinai Hospital of Baltimore, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

23507

Children's Hospital of The King's Daughters, Norfolk

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

Wayne Memorial Hospital, Goldsboro

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

Duke University Medical Center, Durham

27834

East Carolina University, Greenville

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28546

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

29425

Medical University of South Carolina, Charleston

29601

Saint Francis Hospital, Greenville

29605

BI-LO Charities Children's Cancer Center, Greenville

29607

Saint Francis Cancer Center, Greenville

30329

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

32207

Nemours Children's Clinic-Jacksonville, Jacksonville

32504

Nemours Children's Clinic - Pensacola, Pensacola

32610

University of Florida Health Science Center - Gainesville, Gainesville

32803

AdventHealth Orlando, Orlando

32806

Arnold Palmer Hospital for Children, Orlando

32827

Nemours Children's Hospital, Orlando

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33155

Nicklaus Children's Hospital, Miami

33701

Johns Hopkins All Children's Hospital, St. Petersburg

33908

Golisano Children's Hospital of Southwest Florida, Fort Myers

35233

Children's Hospital of Alabama, Birmingham

37203

The Children's Hospital at TriStar Centennial, Nashville

37916

East Tennessee Childrens Hospital, Knoxville

38105

Saint Jude Children's Research Hospital, Memphis

39216

University of Mississippi Medical Center, Jackson

40202

Norton Children's Hospital, Louisville

40536

University of Kentucky/Markey Cancer Center, Lexington

43205

Nationwide Children's Hospital, Columbus

43560

ProMedica Flower Hospital, Sylvania

43606

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

44106

Rainbow Babies and Childrens Hospital, Cleveland

44109

MetroHealth Medical Center, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

Dayton Children's Hospital, Dayton

46202

Riley Hospital for Children, Indianapolis

46260

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

48060

Huron Medical Center PC, Port Huron

48073

Corewell Health Children's, Royal Oak

48109

C S Mott Children's Hospital, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48236

Henry Ford Health Saint John Hospital, Detroit

50309

Blank Children's Hospital, Des Moines

Iowa Methodist Medical Center, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

Children's Hospital of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54601

Gundersen Lutheran Medical Center, La Crosse

55404

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

55905

Mayo Clinic in Rochester, Rochester

60611

Lurie Children's Hospital-Chicago, Chicago

60612

University of Illinois, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61637

Saint Jude Midwest Affiliate, Peoria

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

63104

Cardinal Glennon Children's Medical Center, St Louis

63110

Barnes-Jewish Hospital, St Louis

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64108

Children's Mercy Hospitals and Clinics, Kansas City

68114

Children's Hospital and Medical Center of Omaha, Omaha

68198

University of Nebraska Medical Center, Omaha

70118

Children's Hospital New Orleans, New Orleans

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75230

Medical City Dallas Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

78207

Children's Hospital of San Antonio, San Antonio

79905

El Paso Children's Hospital, El Paso

Texas Tech University Health Sciences Center-El Paso, El Paso

80045

Children's Hospital Colorado, Aurora

80218

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver

83712

Saint Luke's Cancer Institute - Boise, Boise

89048

Hope Cancer Care of Nevada-Pahrump, Pahrump

89052

Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson

89109

Sunrise Hospital and Medical Center, Las Vegas

89135

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas

89144

Summerlin Hospital Medical Center, Las Vegas

89509

Radiation Oncology Associates, Reno

90027

Children's Hospital Los Angeles, Los Angeles

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90242

Kaiser Permanente Downey Medical Center, Downey

90706

Kaiser Permanente-Bellflower, Bellflower

92108

Kaiser Permanente-San Diego Mission, San Diego

92123

Rady Children's Hospital - San Diego, San Diego

92335

Kaiser Permanente-Fontana, Fontana

92354

Loma Linda University Medical Center, Loma Linda

92806

Kaiser Permanente-Anaheim, Anaheim

92868

Children's Hospital of Orange County, Orange

93636

Valley Children's Hospital, Madera

94158

UCSF Medical Center-Mission Bay, San Francisco

94304

Lucile Packard Children's Hospital Stanford University, Palo Alto

94609

UCSF Benioff Children's Hospital Oakland, Oakland

94611

Kaiser Permanente-Oakland, Oakland

95817

University of California Davis Comprehensive Cancer Center, Sacramento

96813

Straub Clinic and Hospital, Honolulu

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97239

Oregon Health and Science University, Portland

98105

Seattle Children's Hospital, Seattle

99204

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

99508

Providence Alaska Medical Center, Anchorage

72202-3591

Arkansas Children's Hospital, Little Rock

06106

Connecticut Children's Medical Center, Hartford

06520

Yale University, New Haven

04401

Eastern Maine Medical Center, Bangor

04412

Lafayette Family Cancer Center-EMMC, Brewer

02114

Massachusetts General Hospital Cancer Center, Boston

02215

Dana-Farber Cancer Institute, Boston

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07601

Hackensack University Medical Center, Hackensack

07960

Morristown Medical Center, Morristown

08903

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick

05405

University of Vermont and State Agricultural College, Burlington

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH