Edoxaban Treatment Versus Vitamin K Antagonist in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

PHASE3CompletedINTERVENTIONAL
Enrollment

1,506

Participants

Timeline

Start Date

February 24, 2017

Primary Completion Date

June 6, 2019

Study Completion Date

June 6, 2019

Conditions
Atrial Fibrillation
Interventions
DRUG

Edoxaban

Edoxaban 60 mg once-daily or 30 mg once-daily in selected subjects

DRUG

Clopidogrel

Clopidogrel 75 mg once-daily

DRUG

Prasugrel

prasugrel 5mg or 10 mg once-daily

DRUG

Ticagrelor

ticagrelor 90 mg twice-daily

DRUG

Vitamin K antagonist

VKA once-daily dosing for target international normalized ratio between 2.0 and 3.0, inclusive

Trial Locations (200)

112

Cheng Hsin General Hospital, Taipei

Taipei Veterans General Hospital, Taipei

220

Far Eastern Memorial Hospital (FEMH), New Taipei City

333

Chang-Gung Memorial Hospital, Taoyuan District

404

China Medical University Hospital (CMUH), Taichung

704

Chi-Mei Medical Center (CMMC), Tainan City

National Cheng Kung University Hospital, Tainan City

807

Kaohsiung medical University Chung-Ho Memorial Hospital (KMUH), Kaohsiung City

824

E-DA Hospital, Kaohsiung City

1023

Budai Irgalmasrendi Kht., Budapest

1070

Hopital Erasme, Brussels

1096

Gottsegen György Országos Kardiológiai Intézet, Budapest

1106

Bajcsy-Zsilinszky Kórház és Rendelőintézet, Budapest

1130

Krankenhaus Hietzing, Vienna

1134

Magyar Honvédség Egészségügyi Központ, Budapest

1160

Wilhelminenspital, Vienna

1601

Oleksandrivska Kiyv City Clinical Hospital, Kyiv

1700

HFR Freiburg - Kantonsspital Kardiologie, Fribourg

2650

University Hospital Antwerp, Edegem

2820

Imelda Ziekenhuis, Bonheiden

3010

General University Hospital of Alicante, Alicante

3500

Virga Jesse Jessa hospital, Hasselt

4032

Debreceni Egyetem Klinikai Központ, Debrecen

4107

Communal Institution of Kyiv Regional Rada, Kyiv

4289

Herzzentrum Leipzig - Universitätsklinik Klinik für Innere Medizin/Kardiologie, Leipzig

4400

Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház, Jósa András Oktatókórház, Nyíregyháza

5700

Békés Megyei Központi Kórház, Gyula

6001

CHU de Nice, Nice

6020

University Hospital Innsbruck, Innsbruck

6725

Szegedi Tudományegyetem, Szeged

6900

Cardiocentro Ticino, Lugano

7624

Pécsi Tudományegyetem, Pécs

7747

Universitätsklinikum Jena Klinik für Innere Medizin I, Kardiologie, Angiologie, Pneumologie, Internistische Intensivmedizin, Jena

8000

AZ St Jan, Bruges

Fejér Megyei Szent György Egyetemi Oktató Kórház, Székesfehérvár

8036

Medizinische Universitaetsklinik Graz, Graz

8230

Állami Szívkórház, Balatonfüred

8800

AZ Delta, Roeselare

8907

Bellvitge University Hospital, L'Hospitalet de Llobregat

8916

Hospital Universitari Germans Trias i Pujol, Badalona

9023

Petz Aladar Megyei Oktato Korhaz, Győr

9300

ASZ Aalst, Aalst

10098

Ospedale degli Infermi di Rivoli, Rivoli

10249

Vivantes Klinikum im Friedrichshaim, Berlin

10380

Inje Univ. Ilsan Paik Hospital, Gyeonggi-do

11000

Clinical Center of Serbia, Belgrade

Clinical Hospital Center -Zvezdara, Belgrade

Institute of CV Diseases Clinical Center of Serbia, Belgrade

12100

A.S.O.S. Croce e Carle Cuneo, Cuneo

12203

Charité Benjamin Franklin, Berlin

13353

Charité, Campus Virchow-Klinikum - Medizinische Klinik mit Schwerpunkt Kardiologie, Berlin

14034

Chernihiv City Hospital #2, Chernihiv

16247

The Catholic University of Korea St.Vincent's Hospital, Gyeonggi-do

18009

Cherkasy regional cardiological center, Cherkasy

18014

Complejo Hospitalario Universitario de Granada, Granada

18057

Universitätsmedizin Rostock, Rostock

20157

Asst Fatebenefratelli-Sacco, Milan

20246

Universitäres Herzzentrum Hamburg GmbH (UHZ), Hamburg

21000

"Communal Institution Vinnytsia Regional Diagnostic Center of cardiovascular disease", Vinnytsia

Vinnytsya Regional Clinical Hospital n.a. Pyrogov, Vinnytsia

21204

Institute of Cardiovascular Diseases of Vojvodina, Kamenitz

21339

Städtisches Klinikum Lüneburg, Lüneburg

23900

Ospedale Alessandro Manzoni-Azienda Ospedaliera di Lecco, Lecco

24068

Bolognini Hospital Seriate, Seriate

24071

Complejo Asistencial Universitario de León, León

25030

Chru Jean Minjoz, Besançon

28034

Hospital Ramon y Cajal, Madrid

28040

Clinica Universitaria San Carlos, Madrid

28046

Hospital La Paz, Madrid, Madrid

28222

Hospital Universitario Puerta de Hierro, Madrid

29000

Khmelnytskyy regional hospital, Khmelnytskyi

29010

Hospital Universitario Virgen de La Victoria, Málaga

30071

Hsinchu Mackay Memorial Hospital (HMMH), Hsinchu

30120

Hospital Universitario Virgen de la Arrixaca, Murcia

31400

Hôpital Rangueil, Service Cancérologie, Toulouse

33007

Communal Institution Rivne Regional Clinical Hospital, Rivne

33098

St. Vincenz-Krankenhaus Paderborn - Medizinische Klinik II, Paderborn

33604

Staedtische Kliniken Bielefeld, Bielefeld

34000

Clinical Center Kragujevac, Kragujevac

35128

Padova University Hospital, Padua

36312

Hospital Álvaro Cunqueiro, Vigo

37007

Hospital Universitario de Salamanca, Salamanca

37126

U.O. Cardiologia Ospedale Borgo Trento, Verona

40031

Communal Institution of Sumy Regional Rada, Sumy

40133

Ospedale Maggiore C.A. Pizzardi -OR - Laboratorio di Cardiologia Interventistica, Bologna

40225

Heinrich-Heine-Universität Düsseldorf - Universitätsklinikum Düsseldorf (UKD) Klinik für Kardiologie, Pneumologie und Angiologie, Düsseldorf

41063

Kliniken Maria Hilf GmbH, Mönchengladbach

41124

AOU Policlinico di Modena, Modena

42117

HELIOS Klinikum Wuppertal - Herzzentrum, Wuppertal

42122

Saint John Emergency Hospital, Bucharest

42472

Daegu Catholic University Hospital, Daegu

43024

Lutsk City Hospital, Lutsk

43126

Azienda Ospedaliero-Universitaria di Parma, Parma

44124

AOU Sant'Anna, Ferrara

44137

St. Johannes- Hospital, Dortmund

46026

Hospital Universitari i Politècnic La Fe, Valencia

47005

Hospital Clínico Universitario de Valladolid, Valladolid

47923

Ospedale degli Infermi, Rimini

48149

Universitätsklinikum Münster - Department für Kardiologie und Angiologie, Münster

49006

"CI Dnipropetrovsk Joint Emergency Hospital", Dnipropetrovsk

49060

Communal Institution Dnepropetrovsk Regional Diagnostic Center, Dnipro

49241

Pusan National University Hospital, Busan

49933

University Hospital of Angers, Angers

50009

Lithuanian University of Health Sciences hospital, Kaunas

50134

Ospedale Careggi, Florence

52074

University Hospital Aachen, Aachen

52100

Ospedale San Donato- ASL 8 Arezzo, Arezzo

53115

GFO Kliniken Bonn - St.-Marien-Hospital, Bonn

53127

Universitätsklinikum Bonn - Medizinische Klinik II - Innere Medizin (Kardiologie, Angiologie und Pneumologie), Bonn

54003

Nikolaev Regional Clinical Hospital, Nikolayev

58013

Chernivtsi Regional Clinical Cardiology Dispensary, Chernivtsi

59300

Clinique Vauban, Valenciennes

61000

"Kharkiv Railway Clinical Hospital N1 of Brance Health Center of the Public joint stock company Ukrainian Railway", Kharkiv

61039

L.T. Malaya Therapy National Institute of the National Academy of medical science of Ukraine, Kharkiv

61058

"Communal Health Care Institution Regional Clinical Hospital - Center of Emergency Medical Care and Disaster Medicine", Kharkiv

61178

Kharkiv City Clinical Hospital #8, Kharkiv

61231

Kerckhoff Klinik, Bad Nauheim

61469

Chonnam National University Hospital, Gwangju

64100

Hopital Cote Basque, Bayonne

65025

Odessa Regional Hospital, Cardiosurgery Center, Odesa

65189

St. Josefs-Hospital - Medizinische Klinik I, Kardiologie, Wiesbaden

66100

ASL2 Chieti - SS Maria Annunziata, Chieti

66421

Universitätsklinikum des Saarlandes Innere Medizin III - Kardiologie, Angiologie und internistische Intensivmedizin, Homburg

67063

Klinikum Ludwigshafen, Ludwigshafen

69000

Zaporizhzhia Regional cardiology dispensary, Zaporizhzhia

69120

Universitätsklinikum Heidelberg Klinik für Kardiologie, Angiologie und Pneumologie (Innere Medizin III), Heidelberg

70124

Policlinico di Bari, Bari

71122

Ospedali Riuniti di Foggia, Foggia

72076

Universitäts Klinikum Tübingen, Tübingen

73000

Metropole Savoie Hospital, Chambéry

75877

Hôpital Bichat - Claude Bernard, Paris

76018

Ivano-Frankivsk Central City Clinical Hospital, Ivano-Frankivsk

76231

Republican Siauliai Hospital, Šiauliai

78052

Schwarzwald-Baar Klinikum - Kliniken Villingen-Schwenningen - Innere Medizin III: Kardiologie und Intensivmedizin, Villingen-Schwenningen

79015

Lviv Regional State Clinical Treatment and Diagnostic Cardiology Center, Lviv

79106

Universitaetsklinikum Freiburg Klinik für Kardiologie und Angiologie I, Freiburg im Breisgau

79189

Universitäts-Herzzentrum Freiburg • Bad Krozingen, Bad Krozingen

80131

University Hospital Federico II, Napoli

81379

Klinik Dr. Müller GmbH & Co. KG, Peter Osypka Herzzentrum, München

88018

Transcarpathian Regional Clinical Cardiology Clinic, Uzhhorod

88100

AOU Materdomini, Magna Graecia University, Catanzaro

89077

Herzklinik Ulm, Ulm

89081

Universitätsklinik Ulm - Zentrum für Innere Medizin - Klinik für Innere Medizin II, Ulm

91106

Centre Hospitalier Sud Francilien, Corbeil-Essonnes

92288

Klaipeda Seamen's Hospital, Klaipėda

94000

Hospital Henri Mondor, Créteil

96450

Klinikum Coburg Med. Klinik Kardiologie, Angiologie, Pneumologie, Coburg

136705

Korea University Anam Hospital, Seoul

280471

Hospital Universitario 12 de Octubre, Madrid

300310

Institutul de Boli Cardiovasculare Timisoara, Timișoara

410169

Oradea Emergency County Clinical Hospital, Oradea

430031

Emergency County Hospital Baia Mare, Baia Mare

431796

Hallym University Sacred Heart Hospital, Gyeonggi-do

540136

Emergency Institute of Cardiovascular Diseases and Transplantation, Târgu Mureş

00168

Policlinico Agostino Gemelli, Roma

00152

S.Camillo Forlanini - Ospedale S.Camillo Reparto di Emodinamica, Rome

05100

"Santa Maria University Hospital - Azienda Ospedaliera Santa Maria Di Terni", Terni

08661

"Vilnius University Hospital Santariskiu Clinic", Vilnius

3435 CM

St Antonius Hospital, Nieuwegein

6525 GA

Radboud university medical center, Nijmegen

3079 DZ

Maasstad Hospital, Rotterdam

2512 VA

MC Haaglanden, The Hague

43-316

II Oddział Kardiologiczny, Polsko-Amerykanskie Kliniki Serca, Bielsko-Biala

32-500

MCSN AHoP, Chrzanów

41-300

III Oddział Kardiologii Inwazyjnej, Angiologii i Elektrokardiologii Polsko-Amerykanskie Kliniki Serca, Dąbrowa Górnicza

47-200

AHP IV DEP K-Kozle, Kędzierzyn-Koźle

31-302

Krakowski Szpital Specjalistyczny im. Jana Pawła II, Oddział Kliniczny Kardiologii Interwencyjnej z Pododdziałem Intenyswengo Nadzoru Kardiologicznego, Krakow

91-302

Nzoz Salus, Lodz

48-300

Nyskie Centrum Sercowo-Naczyniowe, Polsko-Amerykanskie Kliniki Serca, Nysa

96-100

Clin-Medica OMC sp. z o.o. s.k., Skierniewice

43-100

X Oddział Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji Polsko-Amerykanskie Kliniki Serca, Tychy

04-628

Instytut Kardiologii im. Prymasa Tysiaclecia Kardynala Stefana Wyszynskiego, Klinika Choroby Wieńcowej i Strukturalnych Chorób Serca, Warsaw

Instytut Kardiologii im. Prymasa Tysiąclecia Stefana Kardynała Wyszyńskiego; Klinika Kardiologii i Angiologii Interwencyjnej, Warsaw

2805-267

Hospital Garcia de Orta, EPE, Almada

2790-134

Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Santa Cruz, Carnaxide

3000-075

Centro Hospitalar e Universitário de Coimbra, EPE, Coimbra

3041 801

Centro Hospitalar e Universitário de Coimbra, EPE - Hospital dos Covões, Coimbra

1169-024

Centro Hospitalar de Lisboa Central, EPE - Hospital Santa Marta, Lisbon

1649-035

Centro Hospitalar de Lisboa Norte, EPE - Hospital de Santa Maria, Lisbon

022328

"Prof. C.C. Iliescu Emergency Institute for Cardiovascular Diseases", Bucharest

050098

University Hospital of Bucharest, Bucharest

400-711

Inha University Hospital, Incheon

561-712

Chonbuk National University Hospital, Jeonju

136-200

Seoul National University Bundang Hospital, Seongnam

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Seoul

06351

Samsung Medical Centre, Seoul

06591

SEOUL St.Maria, Seoul

07061

Boramae Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

02660

Insititute of Heart of MoH Ukraine, Kyiv

03115

Kyiv City Clinical Hospital#5, Kyiv

03151

State Institution 'National Scientific Central Institute of Cardiology named after MD Strazhesko', Kyiv

04112

Kyiv City Clinical Hospital 4, Kyiv

FY3 8NR

Blackpool Victoria Hospital, Blackpool

CF14 4XW

University Hospital of Wales, Cardiff

G81 4DY

Golden Jubilee Hospital, Clydebank

EH16 4SA

Royal Infirmary of Edinburgh, Edinburgh

BT47 6SB

Altnagelvin Area Hospital, Londonderry

BT63 5QQ

Southern Health and Social Care Trust, Portadown

All Listed Sponsors
lead

Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

INDUSTRY

NCT02866175 - Edoxaban Treatment Versus Vitamin K Antagonist in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention | Biotech Hunter | Biotech Hunter