Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

337

Participants

Timeline

Start Date

September 13, 2016

Primary Completion Date

May 16, 2022

Study Completion Date

October 31, 2025

Conditions
Advanced (Stage IIIB/IV) Non-small Cell Lung Cancer (NSCLC) With MET Exon 14 (METex14) Skipping Alterations or MET AmplificationLung Adenocarcinoma Stage IIIB/IV
Interventions
DRUG

Tepotinib

Subjects will receive 500 milligram (mg) of tepotinib once daily in cycles of 21-day duration until disease progression, death, adverse event (AE) leading to discontinuation or withdrawal of consent.

Trial Locations (177)

2650

UZ Antwerpen, Edegem

7000

CHU Ambroise Paré, Mons

8800

AZ Delta, Roeselare

8816

Somerset Hematology Oncology Associates - Somerville Location, East Brunswick

10022

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Cancer Center, West Harrison Regional Outpatient Pavilion, Harrison

11725

Memorial Sloan Kettering Cancer Center - Commack, Commack

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20817

Center for Cancer and Blood Disorders, Bethesda

22031

Virginia Cancer Specialists, PC, Fairfax

28050

Hospital Universitario HM Madrid Sanchinarro, Madrid

30322

Winship Cancer Institute, Atlanta

30607

University Cancer & Blood Center, LLC, Athens

31059

CHU de Toulouse - Hôpital Larrey, Toulouse

33308

Holy Cross Hospital Inc., Fort Lauderdale

33604

Groupe Hospitalier Sud - Hôpital Haut-Lévêque, Pessac

37203

Tennessee Oncology, Nashville

37232

Vanderbilt University Medical Center, Nashville

41009

Hospital Universitario Virgen Macarena, Seville

44606

Clinique Mutualiste de l'Estuaire, Saint-Nazaire

44805

ICO - Site René Gauducheau, Saint-Herblain

45229

UC Health Clinical Trials Office, Cincinnati

46250

Community Regional Cancer Care, Indianapolis

49055

ICO - Site Paul Papin, Angers

49300

Centre Hospitalier de Cholet, Cholet

56322

Centre Hospitalier de Bretagne Sud, Lorient

59037

Hopital Albert Calmette - CHU Lille, Lille

60637

University of Chicago Medical Center, Chicago

63044

St. Louis Cancer Care, LLP, Bridgeton

63110

Saint Louis University Cancer Center, St Louis

Saint Louis University, St Louis

64100

Centre Hospitalier de la côte Basque, Bayonne

77030

University of Texas MD Anderson Cancer Center, Houston

78731

Texas Oncology, P.A. - Austin, Austin

80218

Rocky Mountain Cancer Centers, LLP, Denver

85925

Centre Hospitalier Départemental Les Oudairies, La Roche-sur-Yon

90277

Torrance Health Association, Redondo Beach

91010

City of Hope Cancer Center, Duarte

92024

California Cancer Associates for Research & Excellence, Inc., Encinitas

95403

St Joseph Heritage Healthcare, Santa Rosa

98104

Swedish Medical Center, Seattle

98801

Wenatchee Valley Hospital & Clinics - ATTN: Jay Johnson, Wenatchee

Wenatchee Valley Medical Center Oncology, Wenatchee

92868-4225

St. Joseph Hospital, Orange

33612-9497

H. Lee Moffitt Cancer Center and Research Institute, Inc, Tampa

60426-3558

Ingalls Hospital, Harvey

Unknown

For Recruiting Locations in the United States, please Contact U.S. Medical Information, Rockland

LKH - Universitätsklinikum der PMU Salzburg - Innere Med III/Hämatologie und Onkologie, Salzburg

UZ Antwerpen, Edegem

CHU Ambroise Paré, Mons

AZ Delta, Roeselare

Beijing Hospital, Beijing

Peking University Cancer Hospital, Beijing

Jilin Cancer Hospital - Oncology, Changchun

Hunan Cancer Hospital, Changsha

Sichuan Cancer Hospital, Chengdu

West China Hospital, Sichuan University, Chengdu

Guangdong General Hospital, Guangzhou

Zhejiang Cancer Hospita, Hangzhou

Affiliated Tumor Hospital of Harbin Medical University, Harbin

Anhui Provincial Cancer Hospital aka West Branch of Anhui Province Hospital, Hefei

Jinan Central Hospital, Jinan

Linyi Tumor Hospital, Linyi

Jiangsu Province Hospital, Nanjing

Shanghai Cancer Hospital, Fudan University, Shanghai

Liaoning Cancer Hospital & Institute, Shenyang

The Affiliated Cancer Hospital of Xinjiang Medical university, Ürümqi

ICO - Site Paul Papin, Angers

Centre Hospitalier de la côte Basque, Bayonne

Centre Hospitalier de Cholet, Cholet

Centre Hospitalier Intercommunal de Créteil, Créteil

Centre Hospitalier Départemental Les Oudairies, La Roche-sur-Yon

Hopital Albert Calmette - CHU Lille, Lille

Centre Hospitalier de Bretagne Sud, Lorient

Hôpital Saint-Louis, Paris

Groupe Hospitalier Sud - Hôpital Haut-Lévêque, Pessac

ICO - Site René Gauducheau, Saint-Herblain

Clinique Mutualiste de l'Estuaire, Saint-Nazaire

CHU de Toulouse - Hôpital Larrey, Toulouse

Charite Universitaetsmedizin Berlin - Campus Charite Mitte, Berlin

Klinikum Chemnitz gGmbH, Chemnitz

For Recruiting Locations outside US, please Contact Merck KGaA Communication Center, Darmstadt

Staedtisches Klinikum Dresden Standort Dresden-Friedrichstadt, Dresden

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

Helios Klinikum Erfurt, Erfurt

Asklepios Fachkliniken Muenchen-Gauting, Gauting

SRH Wald-Klinikum Gera gGmbH, Gera

Universitaetsmedizin Goettingen, Göttingen

Evangelisches Krankenhaus Hamm GmbH, Hamm

Universitaetsklinikum Heidelberg, Heidelberg

Universitaetsklinikum des Saarlandes, Homburg / Saar

POIS Leipzig GbR, Leipzig

Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz, Mainz

Pius-Hospital Oldenburg, Oldenburg

Soroka University Medical Center, Beersheba

Hadassah University Hospital - Ein Kerem, Jerusalem

Meir Medical Center, Kfar Saba

Rabin Medical Center-Beilinson Campus, Petah Tikva

Tel Aviv Sourasky Medical Center, Tel Aviv

Istituto Nazionale per la Ricerca sul Cancro di Genova, Genova

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

IEO Istituto Europeo di Oncologia, Milan

Seconda Università degli Studi di Napoli, Napoli

Azienda Ospedaliera di Padova, Padua

IOV - Istituto Oncologico Veneto IRCCS, Padua

Ospedale Santa Maria di Cà Foncello, Padua

Azienda Ospedaliera San Camillo Forlanini, Roma

Università Campus Bio-Medico di Roma, Roma

Istituto Clinico Humanitas, Rozzano

NHO Kyushu Medical Center, Fukuoka

National Cancer Center Hospital East, Kashiwa-shi

Saitama Cancer Center, Kitaadachi-gun

Kurume University Hospital, Kurume-shi

NHO Shikoku Cancer Center, Matsuyama

Nagoya University Hospital, Nagoya

Niigata Cancer Center Hospital, Niigata

Osaka International Cancer Institute, Osaka

NHO Kinki-Chuo Chest Medical Center, Sakaishi

Hokkaido University Hospital, Sapporo

NHO Yamaguchi - Ube Medical Center, Ube-shi

Kanagawa Cancer Center, Yokohama

Tottori University Hospital, Yonago-shi

Antoni van Leeuwenhoek Ziekenhuis, Amsterdam

VU Medisch Centrum, Amsterdam

Universitair Medisch Centrum Groningen (UMCG) - Parent, Groningen

Uniwersytecki Szpital Kliniczny w Bialymstoku - Dept of Pulmonology & Tuberculosis, Bialystok

Centrum Pulmonologii i Torakochirurgii w Bystrej, Bystra

Dr n med. Slawomir Mandziuk Specjalistyczna Praktyka Lekarska, Lublin

"NZOZ Olsztynski Osr. Onkologiczny Kopernik Sp.z o.o", Olsztyn

Przychodnia Med-Polonia Sp. z o.o., Poznan

Centrum Onkologii-Instytut im. M. Sklodowskiej Curie, Warsaw

Dong-A University Hospital, Busan

Kosin University Gospel Hospital, Busan

Kyungpook National University Medical Center, Daegu

National Cancer Center, Goyang-si

Chonnam National University Hwasun Hospital, Hwasun-gun

Gachon University Gil Medical Center, Incheon

Seoul National University Bundang Hospital, Seongnam-si

Korea University Anam Hospital, Seoul

Samsung Medical Center, Seoul

Severance Hospital, Yonsei University, Seoul

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

The Catholic University of Korea, St. Vincent's Hospital, Suwon

Hospital Universitari Quiron Dexeus, Barcelona

Hospital Universitari Sagrat Cor, Barcelona

Hospital Universitari Vall d'Hebron, Barcelona

Hospital General Universitario Santa Lucia, Cartagena

Hospital de Especialidades de Jerez de la Frontera - Servicio de Oncologia, Jerez de la Frontera

Hospital General Universitario Gregorio Marañon, Madrid

Hospital Universitario 12 de Octubre, Madrid

Hospital Universitario HM Madrid Sanchinarro, Madrid

Hospital Universitario La Paz, Madrid

Hospital Clinico Universitario Virgen de la Victoria, Málaga

Hospital Universitario Infanta Sofia, San Sebastián de los Reyes

Hospital General de Catalunya, Sant Cugat del Vallès

Hospital Universitario Nuestra Señora de Valme, Seville

Hospital Universitario Virgen Macarena, Seville

Inselspital - Universitaetsspital Bern - Klinik und Poliklinik für Medizinische Onkologie, Bern

Universitaetsspital Zuerich - Klinik fuer Onkologie, Zurich

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

China Medical University Hospital, Taichung

Taichung Veterans General Hospital, Taichung

National Taiwan University Hospital, Taipei

Taipei Veterans General Hospital, Taipei

Tri-Service General Hospital, Taipei

07922

Summit Medical Group, P.A., Berkeley Heights

Summit Medical Group, Berkeley Heights

08816

Regional Cancer Care Associates East Brunswick, East Brunswick

07601

Hackensack University Medical Center PARTNER, Hackensack

07432

Prospect Medical Offices, LLC, Midland Park

07450

The Valley Hospital, Ridgewood

45267-0502

University of Cincinnati - PARENT, Cincinnati

77702-1449

Texas Oncology, PA, Beaumont

04357

POIS Leipzig GbR, Leipzig

60-693

Przychodnia Med-Polonia Sp. z o.o., Poznan

02-781

Centrum Onkologii-Instytut im. M. Sklodowskiej Curie, Warsaw

08035

Hospital Universitari Vall d'Hebron, Barcelona

All Listed Sponsors
collaborator

Merck KGaA, Darmstadt, Germany

INDUSTRY

lead

EMD Serono Research & Development Institute, Inc.

INDUSTRY

NCT02864992 - Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION) | Biotech Hunter | Biotech Hunter