Phase II Study to Evaluate Safety and Immunogenicity of a Chikungunya Vaccine

PHASE2CompletedINTERVENTIONAL
Enrollment

263

Participants

Timeline

Start Date

August 17, 2016

Primary Completion Date

September 1, 2017

Study Completion Date

April 16, 2018

Conditions
Chikungunya Virus Infection
Interventions
BIOLOGICAL

MV-CHIK low dose

recombinant measles virus vaccine expressing Chikungunya virus antigens, powder for suspension for injection, 5xE4 (± 0.5 log) TCID50/dose

BIOLOGICAL

MV-CHIK high dose

recombinant measles virus vaccine expressing Chikungunya virus antigens, powder for suspension for injection; 5xE5 (± 0.5 log) TCID50/dose

BIOLOGICAL

Priorix®

lyophilized mixed preparation containing the attenuated Schwarz measles virus strain, the RIT 4385 strain of mumps virus (derived from the Jeryl Lynn strain) and the Wistar RA 27/3 rubella virus strain. Powder and solvent for suspension for injection

BIOLOGICAL

physiological saline solution

sterile physiological saline solution 0.9% used as placebo

Trial Locations (4)

1090

Medical University Vienna, Department of Clinical Pharmacology, Vienna

8010

Hansa Sanatorium GmbH, Graz

10117

Berliner Center for Travel- and Tropical Medicine, Berlin

18057

Medicinal University Rostock, Department for Tropical Medicin and infectious diseases, Rostock

All Listed Sponsors
lead

Themis Bioscience GmbH

INDUSTRY

NCT02861586 - Phase II Study to Evaluate Safety and Immunogenicity of a Chikungunya Vaccine | Biotech Hunter | Biotech Hunter