Anti-VEGF vs. Prompt Vitrectomy for VH From PDR

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

205

Participants

Timeline

Start Date

November 30, 2016

Primary Completion Date

January 31, 2020

Study Completion Date

January 31, 2020

Conditions
Proliferative Diabetic RetinopathyVitreous Hemorrhage
Interventions
DRUG

2-mg Intravitreous Aflibercept Injection

Soluble decoy receptor fusion protein that has a high binding affinity to all isoforms of VEGF as well as to placental growth factor.

PROCEDURE

Prompt Vitrectomy Plus Panretinal Photocoagulation

Surgical removal of the vitreous gel and associated hemorrhage, concurrent delivery of panretinal endolaser

Trial Locations (62)

10003

The New York Eye and Ear Infirmary/Faculty Eye Practice, New York

10021

MaculaCare, New York

Weill Cornell Medical College, New York

13224

Retina-Vitreous Surgeons of Central New York, PC, Syracuse

15146

Retina Vitreous Consultants, Monroeville

21237

Elman Retina Group, P.A., Baltimore

21287

Wilmer Eye Institute at Johns Hopkins, Baltimore

27517

Kittner Eye Center, Chapel Hill

28210

Charlotte Eye, Ear, Nose and Throat Assoc., PA, Charlotte

29169

Palmetto Retina Center, West Columbia

30060

Marietta Eye Clinic, Marietta

30322

Emory Eye Center, Atlanta

30328

Thomas Eye Group, Sandy Springs

30909

Southeast Retina Center, P.C., Augusta

33609

Retina Associates of Florida, P.A., Tampa

33782

Southeast Eye Institute, P.A. dba Eye Associates of Pinellas, Pinellas Park

33805

Florida Retina Consultants, Lakeland

34233

Retina Associates of Sarasota, Sarasota

37421

Southeastern Retina Associates, Chattanooga

37909

Southeastern Retina Associates, P.C., Knoxville

42001

Paducah Retinal Center, Paducah

42690

Raj K. Maturi, MD, PC, Indianapolis

44106

University Hospitals Cleveland Medical Center, Cleveland

44122

Retina Associates of Cleveland, Inc., Beachwood

47150

John-Kenyon American Eye Institute, New Albany

48105

Kellogg Eye Center, University of Michigan, Ann Arbor

48202

Henry Ford Health System, Dept of Ophthalmology and Eye Care Services, Detroit

49546

Retina Specialists of Michigan, Grand Rapids

53226

Medical College of Wisconsin, Milwaukee

55404

Retina Center, PA, Minneapolis

55905

Mayo Clinic Department of Ophthalmology, Rochester

60611

Northwestern Medical Faculty Foundation, Chicago

60612

University of Illinois at Chicago Medical Center, Chicago

61704

Gailey Eye Clinic, Bloomington

61801

Carle Foundation Hospital, Urbana

63128

The Retina Institute, St Louis

64111

Mid-America Retina Consultants, P.A., Kansas City

66204

Retina Associates, P.A., Shawnee Mission

71291

Eye Associates of Northeast Louisiana dba Haik Humble Eye Center, West Monroe

73013

Retina Vitreous Center, Edmond

73104

Dean A. McGee Eye Institute, Oklahoma City

77025

Retina and Vitreous of Texas, Houston

77030

Baylor Eye Physicians and Surgeons, Houston

78240

Medical Center Ophthalmology Associates, San Antonio

Retinal Consultants of San Antonio, San Antonio

78503

Valley Retina Institute, McAllen

78705

Retina Research Center, Austin

79106

Southwest Retina Specialists, Amarillo

79424

Texas Retina Associates, Lubbock

91203

Macula & Retina Institute, Glendale

92354

Loma Linda University Health Care, Department of Ophthalmology, Loma Linda

92647

Atlantis Eye Care, Huntington Beach

93257

Shashi D Ganti, MD PC, Porterville

95008

Retinal Diagnostic Center, Campbell

97221

Retina Northwest, PC, Portland

97239

Casey Eye Institute, Portland

97401

Oregon Retina, LLP, Eugene

99204

Spokane Eye Clinic, Spokane

01432

Valley Eye Physicians and Surgeons, Ayer

02215

Joslin Diabetes Center, Boston

V5Z 3N9

UBC/VCHA Eye Care Centre, Vancouver

M5T 2S8

University Health Network - Toronto Western Hospital, Toronto

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

Regeneron Pharmaceuticals

INDUSTRY

collaborator

National Eye Institute (NEI)

NIH

lead

Jaeb Center for Health Research

OTHER