ARIEL4: A Study of Rucaparib Versus Chemotherapy BRCA Mutant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients

PHASE3CompletedINTERVENTIONAL
Enrollment

349

Participants

Timeline

Start Date

March 1, 2017

Primary Completion Date

December 3, 2020

Study Completion Date

September 16, 2022

Conditions
Ovarian CancerEpithelial Ovarian CancerFallopian Tube CancerPeritoneal Cancer
Interventions
DRUG

Chemotherapy

Chemotherapy will be administered per local standard of care and regulations. Specific comparator will depend on platinum status and investigator decision.

DRUG

Rucaparib

Tablets of rucaparib, at a dose of 600 mg, will be taken orally twice a day

Trial Locations (77)

30912

Augusta University, Augusta

80218

Rocky Mountain Cancer Center, Denver

115478

Moscow Clinical Scientific and Practical Center of Moscow Healthcare Department, Moscow

Unknown

Hospital Haroldo Juacaba Instituto do Cancer do Ceara, Fortaleza

Instituto de Oncologia do Parana (IOP), Curitiba

União Brasileira de Educação e Assistência / Hospital São Lucas da PUCRS, Porto Alegre

CEPON-Centro de pesquisas Oncologicas, Florianópolis

Hospital do Cancer de Barretos, Barretos

Instituto Nacional de Câncer Hospital do Câncer II, Rio de Janeiro

Hospital Pérola Byington - Centro de Referência da Saúde da Mulher, São Paulo

Hospital São Camilo, São Paulo

Tom Baker Cancer Center, Calgary

The Ottawa Hospital - General Campus, Ottawa

Princess Margaret Hospital, Toronto

Centre Hospitalier de L'Universite de Montreal (CHUM), Montreal

CIUSSS de l'Estrie CHUS, Sherbrooke

Masarykuv Onkologicky Ustav, Oddeleni komplexni klinicke onkologie, Brno

Fakultni Nemocnice v Motole, Prague

Fakultní Nemocnice Ostrava, Ostrava

Všeobecná Fakultní Nemocnice v Praze, Prague

Debreceni Egyetem Klinikai Központ, Debrecen

Országos Onkológiai Intézet, Budapest

Carmel Medical Center, Haifa

Edith Wolfson Medical Center, Holon

Hadassah Medical Organization, Jerusalem

Rabin Medical Center, Petah Tikva

Chaim Sheba Medical Center, Ramat Gan

Tel Aviv Sourasky Medical Center, Oncology Dept., Tel Aviv

Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi, Bologna

Istituto per la Ricerca e la Cura del Cancro Istituto di Candiolo, Candiolo

AO per l'emergenza Cannizzaro, Catania

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

Istituto Europeo di Oncologia, Milan

Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena

"Istituto Nazionale per lo studio e la cura dei tumori Fondazione Pascale Oncologia Medica", Napoli

Fondazione Policlinico Universitario Agostino Gemelli, Roma

Niepubliczny Zaklad Opieki Zdrowotnej Innowacyjna Medycyna Sp z o.o., Grzybnica

Bialostockie Centrum Onkologii im. Marii Sklodowskiej-Curie, Bialystok

Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie, Lublin

Wojewodzki Szpital Specjalistyczny w Olsztynie, Olsztyn

Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Pozna, Poznan

Pomorska Akademia Medyczna w Szczecinie, Samodzielny Publiczny Szpital Kliniczny Nr 2, Szczecin

Arkhangelsk Clinical Oncological Dispensary, Arkhangelsk

Kursk Regional Oncologic Dispensary, Kursk

Omsk Region Clinical Oncologic Dispensary, Omsk

Pyatigorsk Oncological Dispensary, Pyatigorsk

Ryazan Regional Clinical Oncology Dispensary, Ryazan

Pavlov First Saint-Petersburg State Medical University, Saint Petersburg

Saint Petersburg City Oncological Dispensary, Saint Petersburg

State Healthcare Institution Oncologic Dispensary No. 2 - Health Department of Krasnodar Region, Saint Petersburg

Republican oncological dispensary of Republic of Mordovia, Saransk

State Healthcare Institution Oncologic Dispensary No. 2 - Health Department of Krasnodar Region, Sochi

Republic Clinical Oncology Dispensary of the Ministry of Healthcare of Republic of Bashkortostan, Ufa

Centro Oncologico Regional de Galicia, A Coruña

Hospital Duran i Reynals, Barcelona

Hospital Universitari Vall DHebron, Barcelona

Hospital Universitari de Girona Doctor Josep Trueta, Girona

Hospital Clinico San Carlos, Madrid

Hospital Universitario Ramón y Cajal, Madrid

MD Anderson Cancer Center, Madrid

Universidad Autonoma de Madrid (UAM) - Hospital Universitario La Paz, Madrid

Dnipropetrovsk City Multifield Clinical Hospital Number 4, Dnipropetrovsk

National Cancer Institute of the Ministry of Health of Ukraine, Kyiv

Volyn Regional Oncology Dispensary, Lutsk

Lviv Regional Oncology Dispensary, Lviv

Sumy Regional Oncology Center, Sumy

Zakarpattya Regional Clinical Oncological Dispensary, Uzhhorod

The Christie NHS Foundation Trust - Clinical Trial Pharmacy, Manchester

The Royal Marsden NHS Foundation Trust, Sutton

Cambridge University Hospitals NHS Foundation Trust, Cambridge

Velindre NHS Trust, Cardiff

University Hospital of Coventry and Warwickshire NHS Trust, Coventry

Derby Teaching Hospital NHS Foundation Trust, Derby

NHS Greater Glasgow and Clyde, Glasgow

University College London Hospitals, London

East and North Hertfordshire NHS Trust, Middlesex

Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Foundation Medicine

INDUSTRY

lead

pharmaand GmbH

INDUSTRY