Improving Pulmonary Function Following Radiation Therapy

NACompletedINTERVENTIONAL
Enrollment

122

Participants

Timeline

Start Date

August 17, 2016

Primary Completion Date

October 28, 2022

Study Completion Date

August 16, 2023

Conditions
Non-Small Cell Lung Cancer
Interventions
OTHER

Laboratory Biomarker Analysis

Correlative studies

RADIATION

Standard fractionation

60-66y Gy delivered in 1.8-2.0 Gy fractions over 30-36 treatments

RADIATION

Stereotactic Body Radiation Therapy (SBRT)

40-60 Gy delivered in 5-20 Gy fractions over 3-8 treatments

PROCEDURE

Four Dimensional Computed Tomographic Imaging (4DCT)

Subjects undergo a total of 7 research-ordered four dimensional computed tomographic imaging (4DCT) scans: 1 at simulation, and 2 scans at each of the 3 post-radiation therapy time points (3, 6, and 12 months). 4DCT determines lung tissue elasticity and for standard of care radiation treatment planning.

Trial Locations (2)

53038

UW Johnson Creek, Johnson Creek

53792

University of Wisconsin Carbone Cancer Center, Madison

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

University of Wisconsin, Madison

OTHER

NCT02843568 - Improving Pulmonary Function Following Radiation Therapy | Biotech Hunter | Biotech Hunter