Evaluation of Preoperative Submucosal Dexamethasone in Third Molar Surgery

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

October 31, 2015

Primary Completion Date

January 31, 2016

Study Completion Date

March 31, 2016

Conditions
Impacted Third Molar Tooth
Interventions
DRUG

dexamethasone acetate

1 milliliter of dexamethasone (4milligram) administered in the deltoid muscle before commencement of surgical procedure

DRUG

submucosal dexamethasone injection

Local anesthesia was achieved using 2% lignocaine hydrochloride and 1:100 000 adrenaline and a standard technique was followed to block Inferior alveolar, lingual and long buccal nerve in all patients. In Group B patients, 1 ml of dexamethasone was administered in submucosa. Investigators divided 1 ml Dexamethasone is into 0.4 milliliter, 0.3 milliliter and 0.3 milliliter parts. Following the local anesthesia, each part of dexamethasone was injected submucosally in the buccal, lingual and retromolar region around the tooth to be extracted. Bone removal done around the tooth using a round bur under copious 0.9% normal saline irrigation and tooth elevated. The flap was sutured using three simple interrupted 3-0 black braided silk suture. All patients were given amoxicillin 500 milligram every 8 hours orally for 5 days, and 500 milligram of paracetamol postoperatively.

PROCEDURE

Third molar surgery

Surgical access was gained through standard Terrence Ward's incision to raise a full thickness mucoperiosteal flap. Bone removal done around the tooth using a round bur under copious 0.9% normal saline irrigation. The tooth sectioned at cemento-enamel junction whenever required and a Coupland elevator is used to elevate tooth or fragmented tooth out of socket. The socket examined for any debris and sharp bony margins smoothened. The empty socket was irrigated copiously and flap was sutured using three simple interrupted 3-0 black braided silk suture.

DRUG

Amoxicillin and paracetamol

Amoxicillin 500 milligram every 8 hours orally for 5 days, and 500 milligram of paracetamol postoperatively (every 6 hours 1 tablet for 2 days).

All Listed Sponsors
lead

Sun Yat-sen University

OTHER

NCT02837614 - Evaluation of Preoperative Submucosal Dexamethasone in Third Molar Surgery | Biotech Hunter | Biotech Hunter