Controlled Human Malaria Infection Model for Evaluation of Transmission-Blocking Interventions - Study 1

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

June 30, 2016

Primary Completion Date

June 29, 2017

Study Completion Date

June 29, 2017

Conditions
Malaria
Interventions
DRUG

Sulfadoxine-pyrimethamine (low dose)

\- subcurative regimen (500mg/25mg)

DRUG

Piperaquine (low dose)

\- subcurative regimen (480 mg)

DRUG

Sulfadoxine-pyrimethamine (high dose)

\- curative regimen (1000mg/50mg)

DRUG

Piperaquine (high dose)

\- curative regimen (960 mg)

BIOLOGICAL

malaria challenge infection, P. falciparum 3D7

malaria challenge infection by P. falciparum 3D7-infected mosquito bites

DRUG

Atovaquone-proguanil

\- curative regimen: 1000/400 mg, for 3 days

Trial Locations (1)

6525 GA

Radboud university medical center, Nijmegen

All Listed Sponsors
collaborator

The PATH Malaria Vaccine Initiative (MVI)

OTHER

collaborator

QIMR Berghofer Medical Research Institute

OTHER

lead

Radboud University Medical Center

OTHER

NCT02836002 - Controlled Human Malaria Infection Model for Evaluation of Transmission-Blocking Interventions - Study 1 | Biotech Hunter | Biotech Hunter