112
Participants
Start Date
July 1, 2016
Primary Completion Date
December 31, 2018
Study Completion Date
March 31, 2019
vonoprazan 20 mg bid
Vonoprazan is potent acid inhibitor. Vonoprazan 20 mg is dosed twice daily for 1 week.
Amoxicillin 500 mg tid
Amoxicillin is antibiotics. Its bactericidal effect is time-dependent. Then, 500 mg of amoxicillin is dosed three times daily for 1 week.
Amoxicillin 750 mg bid
Amoxicillin is antibiotics. Its bactericidal effect is time-dependent. However, the standard regimen in Japan, 750 mg of amoxicillin is dosed twice daily with clarithromycin or metronidazole for 1 week. Then, 750 mg of amoxicillin is dosed twice daily.
Clarithromycin 200 mg bid
Clarithromycin is antibiotics. It is involved in the standard first line regimen in Japan. Then, 200 mg of clarithromycin is dosed twice daily for 1 week.
Metronidazole 250 mg bid
Metronidazole is antimicrobial agent. It is involved in the standard second line regimen in Japan. Then, 250 mg of metronidazole is dosed twice daily for 1 week.
Hamamatsu University School of Medicine, Hamamatsu
Hamamatsu University
OTHER