Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil

PHASE3CompletedINTERVENTIONAL
Enrollment

276

Participants

Timeline

Start Date

May 30, 2017

Primary Completion Date

July 29, 2022

Study Completion Date

July 29, 2022

Conditions
Cognitive DysfunctionMemory Impairment
Interventions
DRUG

Donepezil 5 mg

Participants will be asked to take one 5 mg tablet of donepezil daily for 6 weeks followed by two 5mg tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.

DRUG

Placebo

Participants will be asked to take one tablet of matching placebo daily for 6 weeks followed by two tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.

Trial Locations (278)

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

17870

Geisinger Medical Oncology-Selinsgrove, Selinsgrove

17901

Geisinger Cancer Services-Pottsville, Pottsville

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18510

Community Medical Center, Scranton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19713

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19971

Beebe Health Campus, Rehoboth Beach

19973

TidalHealth Nanticoke / Allen Cancer Center, Seaford

27012

Wake Forest University at Clemmons, Clemmons

27157

Wake Forest University Health Sciences, Winston-Salem

27203

Randolph Hospital, Asheboro

27403

Cone Health Cancer Center, Greensboro

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

28012

Gaston Hematology and Oncology Associates-Belmont, Belmont

28054

CaroMont Regional Medical Center, Gastonia

Gaston Hematology and Oncology Associates, Gastonia

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28546

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

28791

Margaret R Pardee Memorial Hospital, Hendersonville

28792

AdventHealth Hendersonville, Hendersonville

28801

Mission Hospital, Asheville

28803

AdventHealth Infusion Center Asheville, Asheville

28816

Hope Women's Cancer Centers-Asheville, Asheville

29303

Spartanburg Medical Center, Spartanburg

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29341

Gibbs Cancer Center-Gaffney, Gaffney

29379

MGC Hematology Oncology-Union, Union

29440

Tidelands Georgetown Memorial Hospital, Georgetown

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29621

AnMed Health Cancer Center, Anderson

29640

Prisma Health Cancer Institute - Easley, Easley

29646

Self Regional Healthcare, Greenwood

29650

Prisma Health Cancer Institute - Greer, Greer

29651

Gibbs Cancer Center-Pelham, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

33308

Holy Cross Hospital, Fort Lauderdale

37208

Meharry Medical College, Nashville

38120

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

Baptist Memorial Hospital for Women, Memphis

Family Cancer Center-Memphis, Memphis

38652

Baptist Memorial Hospital and Cancer Center-Union County, New Albany

38655

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford

38671

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

39705

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus

40004

Flaget Memorial Hospital, Bardstown

40504

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40741

Saint Joseph London, London

43055

Licking Memorial Hospital, Newark

43214

Columbus Oncology and Hematology Associates Inc, Columbus

Riverside Methodist Hospital, Columbus

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

45714

Strecker Cancer Center-Belpre, Belpre

45750

Marietta Memorial Hospital, Marietta

45840

Armes Family Cancer Center, Findlay

48073

William Beaumont Hospital-Royal Oak, Royal Oak

48085

William Beaumont Hospital - Troy, Troy

48106

Saint Joseph Mercy Hospital, Ann Arbor

48114

IHA Hematology Oncology Consultants-Brighton, Brighton

Saint Joseph Mercy Brighton, Brighton

48118

IHA Hematology Oncology Consultants-Chelsea, Chelsea

Saint Joseph Mercy Chelsea, Chelsea

48124

Beaumont Hospital - Dearborn, Dearborn

48154

Saint Mary Mercy Hospital, Livonia

48188

IHA Hematology Oncology Consultants-Canton, Canton

Saint Joseph Mercy Canton, Canton

48197

IHA Hematology Oncology Consultants-Ann Arbor, Ypsilanti

48230

William Beaumont Hospital-Grosse Pointe, Grosse Pointe

48336

Beaumont Hospital - Farmington Hills, Farmington Hills

48341

Newland Medical Associates-Pontiac, Pontiac

Saint Joseph Mercy Oakland, Pontiac

48346

Hematology Oncology Consultants-Clarkston, Clarkston

Newland Medical Associates-Clarkston, Clarkston

48503

Genesee Cancer and Blood Disease Treatment Center, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48604

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48723

Caro Cancer Center, Caro

48764

Ascension Saint Joseph Hospital, Tawas City

49444

Mercy Health Mercy Campus, Muskegon

49503

Mercy Health Saint Mary's, Grand Rapids

Spectrum Health at Butterworth Campus, Grand Rapids

49519

Metro Health Hospital, Wyoming

49677

Spectrum Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

49829

Green Bay Oncology - Escanaba, Escanaba

50309

Iowa Methodist Medical Center, Des Moines

Medical Oncology and Hematology Associates-Des Moines, Des Moines

50314

Broadlawns Medical Center, Des Moines

Mercy Medical Center - Des Moines, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

52402

Physicians' Clinic of Iowa PC, Cedar Rapids

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53142

Aurora Cancer Care-Kenosha South, Kenosha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

54017

Cancer Center of Western Wisconsin, New Richmond

54143

Aurora Bay Area Medical Group-Marinette, Marinette

Saint Vincent Hospital Cancer Center at Marinette, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54221

Holy Family Memorial Hospital, Manitowoc

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54311

Aurora BayCare Medical Center, Green Bay

54401

Marshfield Clinic-Wausau Center, Wausau

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Clinic Stevens Point Center, Stevens Point

54494

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54548

Marshfield Clinic-Minocqua Center, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54729

Marshfield Clinic-Chippewa Center, Chippewa Falls

54848

Marshfield Clinic - Ladysmith Center, Ladysmith

54868

Marshfield Medical Center-Rice Lake, Rice Lake

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54937

Aurora Health Center-Fond du Lac, Fond du Lac

55082

Lakeview Hospital, Stillwater

55092

Fairview Lakes Medical Center, Wyoming

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61520

Illinois CancerCare-Canton, Canton

61554

Illinois CancerCare-Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle on Vermilion, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62801

Centralia Oncology Clinic, Centralia

63131

Missouri Baptist Medical Center, St Louis

65109

Capital Region Southwest Campus, Jefferson City

65804

Mercy Hospital Springfield, Springfield

66502

Cancer Center of Kansas-Manhattan, Manhattan

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

68847

CHI Health Good Samaritan, Kearney

70112

Louisiana State University Health Science Center, New Orleans

University Medical Center New Orleans, New Orleans

70121

Ochsner Medical Center Jefferson, New Orleans

70805

LSU Health Baton Rouge-North Clinic, Baton Rouge

70809

Louisiana Hematology Oncology Associates LLC, Baton Rouge

Mary Bird Perkins Cancer Center, Baton Rouge

Our Lady of the Lake Physicians Group - Medical Oncology, Baton Rouge

71105

CHRISTUS Highland Medical Center, Shreveport

71301

Christus Saint Frances Cabrini Hospital, Alexandria

80026

Kaiser Permanente-Rock Creek, Lafayette

80122

Littleton Adventist Hospital, Littleton

80124

Kaiser Permanente-Lone Tree, Lone Tree

80138

Parker Adventist Hospital, Parker

80205

Kaiser Permanente-Franklin, Denver

80210

Porter Adventist Hospital, Denver

80501

Longmont United Hospital, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90034

Kaiser Permanente West Los Angeles, Los Angeles

90706

Kaiser Permanente-Bellflower, Bellflower

90710

Kaiser Permanente - Harbor City, Harbor City

91367

Kaiser Permanente-Woodland Hills, Woodland Hills

91402

Kaiser Permanente - Panorama City, Panorama City

91706

Kaiser Permanente-Baldwin Park, Baldwin Park

91761

Kaiser Permanente-Ontario, Ontario

92078

Kaiser Permanente-San Marcos, San Marcos

92120

Kaiser Permanente-San Diego Zion, San Diego

92335

Kaiser Permanente-Fontana, Fontana

92505

Kaiser Permanente-Riverside, Riverside

92618

Kaiser Permanente-Irvine, Irvine

92806

Kaiser Permanente-Anaheim, Anaheim

93720

Fresno Cancer Center, Fresno

Kaiser Permanente-Fresno, Fresno

94080

Kaiser Permanente-South San Francisco, South San Francisco

94115

Kaiser Permanente-San Francisco, San Francisco

94531

Kaiser Permanente-Deer Valley Medical Center, Antioch

94538

Kaiser Permanente-Fremont, Fremont

94577

Kaiser Permanente San Leandro, San Leandro

94589

Kaiser Permanente-Vallejo, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente-Oakland, Oakland

94801

Kaiser Permanente-Richmond, Richmond

94903

Kaiser Permanente-San Rafael, San Rafael

Kaiser San Rafael-Gallinas, San Rafael

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95210

Kaiser Permanente-Stockton, Stockton

95356

Kaiser Permanente-Modesto, Modesto

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

95661

Kaiser Permanente-Roseville, Roseville

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95688

Kaiser Permanente Medical Center-Vacaville, Vacaville

95814

Kaiser Permanente Downtown Commons, Sacramento

95823

Kaiser Permanente-South Sacramento, Sacramento

South Sacramento Cancer Center, Sacramento

95825

Kaiser Permanente - Sacramento, Sacramento

96701

Pali Momi Medical Center, ‘Aiea

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Hawaii Cancer Care Inc-Liliha, Honolulu

Queen's Cancer Center - Kuakini, Honolulu

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97227

Kaiser Permanente Northwest, Portland

50266-7700

Methodist West Hospital, West Des Moines

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

54235-1495

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Wake Forest University Health Sciences

OTHER

NCT02822573 - Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil | Biotech Hunter | Biotech Hunter