PDE5 Inhibition for Obesity-Related Cardiometabolic Dysfunction

PHASE2CompletedINTERVENTIONAL
Enrollment

141

Participants

Timeline

Start Date

July 31, 2016

Primary Completion Date

June 30, 2020

Study Completion Date

June 30, 2020

Conditions
HealthyObese
Interventions
DRUG

Tadalafil

Tadalafil is an FDA approved, clinically-available drug that inhibits the enzyme phosphodiesterase type 5A (PDE5). Subjects who are randomized to this arm will be provided with 20mg of Tadalafil to take every day for 12 weeks, beginning at their baseline visit.

DRUG

Placebo

100 patients will be randomized to receive a placebo pill. Subjects in this arm will be provided with 20mg Placebo to take every day for 12 weeks, beginning at their baseline visit.

Trial Locations (1)

37215

Vanderbilt University Medical Center, Nashville

All Listed Sponsors
lead

Vanderbilt University Medical Center

OTHER

NCT02819440 - PDE5 Inhibition for Obesity-Related Cardiometabolic Dysfunction | Biotech Hunter | Biotech Hunter