Safety and Tolerability of Atezolizumab (ATZ) in Combination With Radium-223 Dichloride (R-223-D) in Metastatic Castrate-Resistant Prostate Cancer (CRPC) Progressed Following Treatment With an Androgen Pathway Inhibitor

PHASE1CompletedINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

September 23, 2016

Primary Completion Date

July 31, 2019

Study Completion Date

July 31, 2019

Conditions
Castrate-Resistant Prostate Cancer
Interventions
DRUG

Atezolizumab

Atezolizumab will be given at a dose of 840 milligrams (mg) via intravenous (IV) infusion on Days 1 and 15 of each 28-day cycle until loss of clinical benefit, unacceptable toxicity, or disease progression.

DRUG

Radium-223 Dichloride

Radium-223 dichloride will be administered at a dose of 55 kilobecquerels per kilogram (kBq/kg) via slow IV bolus on Day 1 of each 28-day cycle for up to 6 cycles.

Trial Locations (17)

11725

Memorial Sloan-Kettering Cancer Center, Commack

19107

Thomas Jefferson University Hospital, Philadelphia

20007

Georgetown University Medical Center, Washington D.C.

27710

Duke University Hospital, Durham

32224

Mayo Clinic Hospital - Florida, Jacksonville

37232

Vanderbilt University Medical Center, Nashville

46202

Indiana University Health Melvin & Bren Simon Cancer Center, Indianapolis

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

Karmanos Cancer Institute, Detroit

55905

Mayo Clinic - Minnesota, Rochester

89169

Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley, Las Vegas

91010

City of Hope, Duarte

94158

University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco

98195

University of Washington, Seattle

06510

Yale School of Medicine, New Haven

70112-2600

Tulane University School of Medicine, New Orleans

15232-1301

University of Pittsburgh - Hillman Cancer Center, Pittsburgh

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02814669 - Safety and Tolerability of Atezolizumab (ATZ) in Combination With Radium-223 Dichloride (R-223-D) in Metastatic Castrate-Resistant Prostate Cancer (CRPC) Progressed Following Treatment With an Androgen Pathway Inhibitor | Biotech Hunter | Biotech Hunter