A Study of CA-170 (Oral PD-L1, PD-L2 and VISTA Checkpoint Antagonist) in Patients With Advanced Tumors and Lymphomas

PHASE1CompletedINTERVENTIONAL
Enrollment

71

Participants

Timeline

Start Date

May 31, 2016

Primary Completion Date

May 7, 2020

Study Completion Date

May 7, 2020

Conditions
Advanced Solid Tumors or Lymphomas
Interventions
DRUG

CA-170

"Dose escalation stage (Phase 1a) accelerated titration and standard 3+3 dose escalation in patients with advanced solid tumor or lymphoma.~Dose expansion stage (Phase 1b) in patients with tumors that are shown to be responsive to anti-PD-1 or anti-PD-L1 checkpoint inhibitors and/or in tumor types known to express PD-L1 or VISTA, including but not limited to: mesothelioma, melanoma, non-small cell lung cancer, renal cell carcinoma, Hodgkin lymphoma, triple negative breast cancer, head and neck cancer, colorectal cancer, gastric cancer, bladder cancer, and ovarian cancer."

Trial Locations (20)

3722

Yonsei University Health System - Severance Hospital, Seoul

5505

Asan Medical Center, Seoul

10029

Icahn School of Medicine at Mt. Sinai, New York

10065

Memorial Sloan Kettering Cancer Center, New York

15237

University of Pittsburgh Medical Center, Pittsburgh

28041

Hospital Universitario 12 de Octubre, Madrid

28078

Carolina BioOncology Institute, Huntersville

34232

Sarah Cannon Research Institute, Sarasota

37203

Sarah Cannon Research Institute, Nashville

48201

Karmanos Cancer Institute, Detroit

60208

Northwestern University, Chicago

77030

University of Texas MD Anderson Cancer Center, Houston

80218

Sarah Cannon Research Institute at HealthONE, Denver

94143

University of California San Francisco, San Francisco

03080

Seoul National University Hospital, Seoul

06351

Samsung Medical Center, Seoul

08036

Hospital Clinic i Provincial, Barcelona

08907

Catalan Institute of Oncology, Barcelona

CB2 0QQ

Cambridge University Hospitals NHS Foundation Trust, Cambridge

SE1 9RT

Guy's and St Thomas' NHS Foundation Trust, London

All Listed Sponsors
lead

Curis, Inc.

INDUSTRY

NCT02812875 - A Study of CA-170 (Oral PD-L1, PD-L2 and VISTA Checkpoint Antagonist) in Patients With Advanced Tumors and Lymphomas | Biotech Hunter | Biotech Hunter