Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Sunitinib Alone as Treatment of Advanced Renal Cell Carcinoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,069

Participants

Timeline

Start Date

October 13, 2016

Primary Completion Date

August 28, 2020

Study Completion Date

March 31, 2026

Conditions
Renal Cell Carcinoma
Interventions
DRUG

Lenvatinib

DRUG

Everolimus

DRUG

Pembrolizumab

DRUG

Sunitinib

Trial Locations (183)

1000

Institut Jules Bordet, Brussels

1090

AKH - Medizinische Universität Wien, Vienna

2260

ZNA Middelheim, Antwerp

2610

GZA Ziekenhuizen - Campus Sint-Augustinus, Wilrijk

3084

Austin Health, Heidelberg

3128

Box Hill Hospital, Box Hill

3500

Jessa Ziekenhuis - Campus Virga Jesse, Hasselt

4000

Domaine Universitaire, Liège

4805

Boulevard du Professeur Jacques Monod, Saint-Herblain

10003

Hospital San Pedro de Alcantara, Cáceres

10021

Weill Cornell Medical College New York Presbyterian Hospital, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10461

Montefiore Medical Center, The Bronx

11528

"General Hospital of Athens Alexandra", Athens

12200

EISAI Trial site 5, Berlin

13790

Broome Oncology, Johnson City

14263

Rosewell Park Cancer Institute, Buffalo

16132

Istituto Nazionale per la Ricerca sul Cancro di Genova, Genova

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20817

Associates in Oncology & Hematology, PC, Bethesda

21079

Centre Georges François Leclerc, Dijon

26504

University of Patras Medical School, Pátrai

28034

Hospital Universitario Ramon y Cajal, Madrid

28801

Mission Hospital_ Cancer Care of Western North Carolina, Asheville

29412

Medical University of South Carolina, Charleston

30625

EISAI Trial site 8, Hanover

32804

Florida Hospital Cancer Institute, Orlando

33011

Hospital Universitario Central de Asturias, Oviedo

33136

University of Miami, Miami

Mount Sinai Medical Center, Miami Beach

33170

Azienda Ospedaliera Santa Maria Degli Angeli, Pordenone

33401

Florida Cancer Specialists, West Palm Beach

33486

Boca Raton Community Hospital, Boca Raton

33705

Florida Cancer Specialists ( North Region), St. Petersburg

33901

Florida Cancer Specialists, Fort Myers

37203

SCRI - Tennessee Oncology, Nashville

39008

Hospital Universitario Marques de Valdecilla, Santander

41124

A.O.U. Policlinico di Modena, Modena

41404

Kyungpook National University Chilgok Hospital, Daegu

45242

Oncology Hematology Care, Cincinnati

46009

Oncologia, Valencia

48018

Azienda Unità Sanitaria Locale- Ravenna, Faenza

48149

EISAI Trial site 13, Münster

48201

Karmanos Cancer Center, Detroit

49055

ICO - Site Paul Papin, Angers

49100

Rabin Medical Center-Beilinson Campus, Petah Tikva

56429

General Hospital Papageorgiou, Thessaloniki

57001

Interbalkan Hospital of Thessaloniki, Thessaloniki

60435

Joliet Oncology - Hematology Associates, Joliet

60487

Healthcare Research Network III, LLC, Tinley Park

60590

EISAI Trial site 6, Frankfurt am Main

66209

Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Division, LLC, Overland Park

66421

EISAI Trial site 2, Homburg/Saar

66604

Cotton-Oneil Clinical Research Center, Topeka

68130

GU Research Network, Omaha

Nebraska Cancer Specialists, Omaha

70121

Ochsner Clinic Foundation, New Orleans

70174

EISAI Trial site 4, Stuttgart

72076

EISAI Trial site 1, Tübingen

73100

Presidio Ospedaliero Vito Fazzi, Lecce

75231

Texas Oncology, P.A., Dallas

75460

Texas Oncology PA - Paris, Paris

75702

Texas Oncology PA - Tyler, Tyler

76104

Texas Oncology PA, Fort Worth

77380

USOR Texas Oncology, The Woodlands

78503

Texas Oncology PA - McAllen, McAllen

80131

Azienda Ospedaliera di Rilievo Nazionale A. Cardarelli, Napoli

81377

EISAI Trial site 7, München

115478

FSBSI Russian Oncological Scientific Center n.a. N.N. Blokhin - Department of Oncology, Moscow

125284

"FSBI Moscow scientific research oncology institute n.a. P.A. Gertsen of MoH of RF", Moscow

249036

"FSBI National Medical Research Radiological Center of the MoH of the RF", Obninsk

630108

"SBHI of Novosibirsk region Novosibirsk Regional Oncological Dispensary", Novosibirsk

644013

"BHI of Omsk region Clinical Oncology Dispensary", Omsk

94305-5826

Stanford School of Medicine, Stanford

02214

Massachusetts General Hospital- MGH, Boston

02215

Dana Farber Cancer Institute, Boston

07601

Hackensack Medical Center, Hackensack

Unknown

Royal Hobart Hospital, Hobart

Macquarie University Hospital, Macquarie Park

ICON Cancer Foundation, South Brisbane

Sunshine Hospital, St Albans

Medizinische Universitat Innsbruck, Innsbruck

Krankenhaus der barmherzigen Schwestern Linz, Linz

O.L.V Ziekenhuis, Aalst

Imeldaziekenhuis, Bonheiden

Fakultni nemocnice u sv. Anny v Brne, Brno

Masarykuv onkologicky ustav, Brno

Fakultni nemocnice Olomouc, Neurologicka klinika, Olomouc

Fakultni nemocnice v Motole, Prague

Nemocnice Na Bulovce, Prague

Thomayerova nemocnice, Prague

Clinique Victor Hugo - Centre Jean Bernard, Le Mans

Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-Alpes, Lyon

Institut Regional du Cancer de Montpellier, Montpellier

Hopital Europeen Georges Pompidou, Paris

CHU Strasbourg - Nouvel Hopital Civil, Strasbourg

EISAI Trial site 14, Greifswald

Cork University Hospital,Wilton, Cork

Adelaide and Meath Hospital Incorp The National Children's Hospital, Dublin

Beaumont Hospital, Dublin

University Hospital Galway, Galway

Assaf Harofeh Medical Center, Be’er Ya‘aqov

Rambam MC, Haifa

Sapir Medical Center, Meir Hospital, Kfar Saba

Chaim Sheba Medical Center, Ramat Gan

Tel Aviv Sourasky Medical Center, Tel Aviv

Ospedale San Donato, Arezzo

Azienda Ospedaliera Universitaria Policlinico SantOrsola Malpighi, Bologna

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori - IRST, Meldola

Istituto Nazionale Tumori Fondazione G. Pascale, Napoli

Fondazione IRCCS Policlinico San Matteo, Pavia

I.R.C.S.S Fondazione Maugeri, Pavia

Azienda Ospedaliera San Camillo Forlanini, Roma

Universita Campus Bio-Medico di Roma, Rome

Facility #1, Aichi

Facility #1, Akita

Facility #1, Aomori

Facility #2, Chiba

Facility #1, Fukuoka

Facility #1, Hiroshima

Facility #1, Hokkaido

Facility #2, Hokkaido

Facility #1, Hyōgo

Facility #1, Kagawa

Facility #2, Kanagawa

Facility #3, Kanagawa

Facility #1, Nagasaki

Facility #1, Nara

Facility #1, Niigata

Facility #1, Okayama

Facility #1, Osaka

Facility #2, Osaka

Facility #1, Saitama

Facility #1, Tokushima

Facility #1, Tokyo

Facility #2, Tokyo

Facility #3, Tokyo

Facility #4, Tokyo

Facility #5, Tokyo

Facility #6, Tokyo

Uniwersyteckie Centrum Kliniczne, Gdansk

Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin

SPWSZ w Szczecinie im. Marii Sklodowskiej-Curie, Szczecin

FSBSI Russian Oncological Scientific Center n.a. N.N. Blokhin - Department of Urology, Moscow

FBHI Privolzhskiy District Medical Centre FMBA of Russia, Nizhny Novgorod

National Cancer Center, Goyang-si

Asan Medical Center: Medical Oncology Department, Seoul

Asan Medical Center: Urology Department, Seoul

Department of Internal Medicine Division of Hematology/Oncology Cancer center 11F, Seoul

Samsung Medical Center, Seoul

Seoul National University Hospital, Seoul

Severance Hospital, Yonsei University Health System, Seoul

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

Hospital de la Santa Creu i Sant Pau, Barcelona

Hospital Universitari Vall d'Hebron, Barcelona

Hospital Universitario Reina Sofia, Córdoba

Hospital General Universitario Gregorio Maranon, Madrid

Hospital Universitario Clinico San Carlos, Madrid

Hospital Universitario HM Madrid Sanchinarro, Madrid

MD Anderson Cancer Centre, Madrid

Hospital Universitario Virgen del Rocio, Seville

Inselspital - Universitaetsspital Bern, Bern

Royal Bournemouth General Hospital, Bournemouth

Velindre Cancer Centre, Cardiff

Western General Hospital, Edinburgh

Guy's Hospital, London

Royal Free Hospital, London

T6G 1Z2

Cross Cancer Institute, Edmonton

V5Z 1H7

BC Cancer Agency Vancouver Centre, Vancouver

L8N 4A6

St. Joseph's Healthcare Hamilton, Hamilton

N6A4L6

London Institute of Health Sciences, London

K1H 8

Ottawa Hospital Cancer Centre, Ottawa

M4N 3M5

Sunnybrook Research Institute - University of Toronto, Toronto

J4V 2H1

Centre de santé et de services sociaux Champlain-Charles-Le Moyne, Greenfield Park

cedex 13 75651

Hopital la Petie Salpetriere, Paris

1066 CX

Antoni van Leeuwenhoek, Amsterdam

1081 HV

VU Medisch Centrum, Amsterdam

3584 CX

UMC Utrecht, Utrecht

08036

Hospital Clinic i Provincial de Barcelona, Barcelona

08908

ICO l'Hospitalet - Hospital Duran I Reynals, Barcelona

G12 0YN

Beatson West Of Scotland Cancer Centre, Glasgow

LS9 7TF

St. James's University Hospital, Leeds

M20 4BX

Christie Hospital NHS Foundation Trust, Manchester

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Eisai Inc.

INDUSTRY