1,213
Participants
Start Date
June 30, 2016
Primary Completion Date
August 31, 2022
Study Completion Date
February 12, 2024
Atezolizumab
Atezolizumab will be administered at a fixed dose of 1200 milligrams (mg) by intravenous (IV) infusion on Day 1 of each 21-day cycle until investigator-assessed disease progression per RECIST v1.1. In specific circumstances treatment may continue beyond disease progression.
Carboplatin
Carboplatin will be administered at doses to achieve area under the concentration-time curve (AUC) of 4.5 milligram per milliliter into minute (mg/mL\*min) by IV infusion on Day 1 of each 21-day cycle until investigator-assessed disease progression per RECIST v1.1 or unacceptable toxicity.
Gemcitabine
Gemcitabine will be administered at a dose of 1000 milligrams per square meter (mg/m\^2) by IV infusion on Day 1 and Day 8 of each 21-day cycle, until investigator-assessed disease progression per RECIST v1.1 or unacceptable toxicity.
Placebo
Placebo matched to atezolizumab will be administered by IV infusion on Day 1 of each 21-day cycle until investigator-assessed disease progression per RECIST v1.1. In specific circumstances treatment may continue beyond disease progression.
Cisplatin
Cisplatin will be administered at a dose of 70 mg/m\^2 by IV infusion on Day 1 of each 21-day cycle until investigator-assessed disease progression per RECIST v1.1 or unacceptable toxicity.
Clinica Alemana, Vitacura
Chang Gung Medical Foundation-Linkou, Urinary Oncology, Taoyuan District
Taichung Veterans General Hospital, Taichung
National Cheng Kung Uni Hospital, Tainan City
Institute of Oncology Ljubljana, Ljubljana
Macquarie University Hospital, Macquarie University
Sandton Oncology Medical Group, Sandton
UZ Leuven Gasthuisberg, Leuven
Box Hill Hospital, Box Hill
Cabrini Medical Centre, Malvern
CHC MontLégia, Liège
Royal Brisbane and Women's Hospital, Herston
Lyell McEwin Hospital, Adelaide
Cancercare, Port Elizabeth
AZ Sint Lucas (Sint Lucas), Ghent
Hospital San Pedro De Alcantara, Cáceres
Mount Sinai School of Medicine - Tisch Cancer Institute, New York
National Taiwan Uni Hospital, Taipei
A.O CITTA' DELLA SALUTE E DELLA SCIENZA D. - Presidio San Lazzaro, Turin
East Tallinn Central Hospital, Tallinn
Vajira Hospital, Bangkok
Chulalongkorn Hospital, Bangkok
Faculty of Med. Siriraj Hosp., Bangkok
Clinical Center of Serbia, Belgrade
Alexandras General Hospital of Athens, Athens
Hospital Provincial de Castellon, Castellon
North Estonia Medical Centre Foundation, Tallinn
Hospital Universitario Reina Sofia, Córdoba
University Hospital Motol, Prague
Az. Osp. Uni Ria San Martino, Genoa
Clinical Centre Nis, Clinic for Oncology, Niš
Hospital Universitario Virgen de las Nieves, Granada
Christina Care Institutional Review Board, Newark
Istituto Clinico Humanitas, Rozzano
Irccs Istituto Nazionale Dei Tumori (Int), Milan
Turku Uni Central Hospital, Turku
Oncology Institute of Vojvodina, Kamenitz
Gachon University Gil Medical Center, Incheon
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi, Edirne
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico, Jaén
Complejo Asistencial Universitario de Leon, León
Hospital Universitario Lucus Augusti, Lugo
University of North Carolina, Lineberger Cancer Ctr, Chapel Hill
Hospital General Universitario Gregorio Marañon, Madrid
Hospital Ramon y Cajal, Madrid
Hospital Universitario Clínico San Carlos, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitario La Paz, Madrid
Bon Secours - St. Francis Hospital, Greenville
Clinica Universitaria de Navarra, Pamplona
UF Health Cancer Center at Orlando Health, Orlando
Moffitt Cancer Center, Tampa
Florida Cancer Specialists (St. Petersburg ? St. Anthony?s Professional Building), St. Petersburg
Florida Cancer Specialists, Fort Myers
Bezmi Alem Vakif University Medical School, Istanbul
Istanbul University Cerrahpa?a-Cerrahpa?a Medical Faculty, Istanbul
IRCCS Istituto Oncologico Veneto (IOV), Padua
Hospital Alvaro Cunqueiro, Vigo
Sarah Cannon Research Institute / Tennessee Oncology, Nashville
Hospital Universitario Marques de Valdecilla, Santander
Norton Cancer Institute, Louisville
China Medical University Hospital, Taichung
Hospital Universitario Virgen del Rocio, Seville
A.O. Universitaria Policlinico Di Modena, Modena
Kyungpook National University Medical Center, Daegu
Hospital Universitario de Toledo, Toledo
Consultorio Médico, Zapopan
Hospital Universitario la Fe, Valencia
Parkview Research Center, Fort Wayne
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola, Meldola
Hospital de Basurto, Bilbao
CI Dnipropetrovsk CMCH #4 MA of MOHU Ch of Oncology and MR, Dnipropetrovsk
Hospital Clinico Universitario Lozano Blesa, Zaragoza
Hospital Universitario Miguel Servet, Zaragoza
Maharaj Nakorn Chiang Mai Hospital, Chiang Mai
Hospital Kuala Lumpur, Kuala Lumpur
Azienda USL8 Arezzo-Presidio Ospedaliero 1 San Donato, Arezzo
19 Mayis University Medical Faculty, Samsun
Park Nicollet Clin-Cancer Ctr, Saint Louis Park
University Malaya Medical Centre, Kuala Lumpur
Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval Department of Urology #4, Kharkiv
Zaporizhzhia Regional Clinic, Zaporizhzhia
East Jefferson Hematology Oncology, Metairie
Clinical center University of Sarajevo, Sarajevo
IRCCS Ospedale Casa Sollievo Della Sofferenza, San Giovanni Rotondo
Highlands Oncology Group, Rogers
Cancerología, Querétaro
Azienda Ospedaliera A. Cardarelli, Napoli
Comprehensive Cancer Centers of Nevada, Las Vegas
Oulu University Hospital, Oulu
Coastal Integrative Cancer Care, San Luis Obispo
Beijing Friendship Hospital, Beijing
Peking Union Medical College Hospital, Beijing
Blokhin Cancer Research Center, Moscow
Russian Scientific Center of Roentgenoradiology, Moscow
National University Hospital, Singapore
P.A. Herzen Oncological Inst., Moscow
Ivanovo Regional Oncology Dispensary, Ivanovo
National Cancer Centre, Singapore
"SBEI HPE The First St.Petersburg State Medical University n.a. acad. I.P.Pavlovaof MoH of RF", Saint Petersburg
Fudan University Shanghai Cancer Center, Shanghai
Zhongshan Hospital Fudan University, Shanghai
Huadong Hospital Affiliated to Fudan University, Shanghai
Oncology Center Sf. Nectarie, Craiova
The 2nd Hospital of Tianjin Medical University, Tianjin
Jiangsu Cancer Hospital, Nanjing
Chongqing Cancer Hospital, Chongqing
Spitalul Judetean de Urgenta Dr Constantin Opris, Baia Mare
SBEI of HPE ?Bashkir State Medical University? of MoH RF, Ufa
Sun Yat-sen Memorial Hospital, Guangzhou
Privolzhsk Regional Medical Center, Nizhny Novgorod
Sverdlovsk Regional Clinical Hospital 1, Yekaterinburg
Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky, Krasnoyarsk
Rambam Health Care Campus, Haifa
OrlandiOncología, Santiago
Bradford Hill Centro de Investigaciones Clinicas, Recoleta
CETUS Hospital Dia Oncologia, Belo Horizonte
Yale School of Medicine, New Haven
Norwalk Hospital, Norwalk
Sunshine Hospital, St Albans
Princess Margaret Hospital, Hong Kong
Queen Elizabeth Hospital, Hong Kong
Queen Mary Hospital, Hong Kong
The Chinese University of Hong Kong, Hong Kong
Oncocare Cancer Centre, Singapore
Chang Gung Medical Foundation - Kaohsiung, Kaohisung
GHdC Site Notre Dame, Charleroi
Hospital Luxemburgo, Belo Horizonte
Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda, Ijuí
Hospital das Clinicas - UFRGS, Porto Alegre
Hospital Nossa Senhora da Conceicao, Porto Alegre
Clinica Viver, Santa Maria
Clinica de Neoplasias Litoral, Itajaí
Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto
Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo
Beneficencia Portuguesa de Sao Paulo, São Paulo
Clinicas Oncologicas Integradas - COI, Rio de Janeiro
Arthur J.E. Child Comprehensive Cancer Center-Calgary, Calgary
Cross Cancer Institute, Edmonton
BC Cancer Agency, CSI, Kelowna
Dr. Georges L. Dumont University Hospital Centre, Moncton
Juravinski Cancer Clinic, Hamilton
Lakeridge Health Center, Oshawa
North York General Hospital, Toronto
Fundacion Arturo Lopez Perez, Santiago
Masarykuv onkologicky ustav, Brno
Fakultni nemocnice Olomouc, Olomouc
Vseobecna fakultni nemocnice v Praze, Prague
Research institute for Clinical Medicine, Tbilisi
National Center of Urology, Tbilisi
University Hospital of Patras Medical Oncology, Pátrai
Policlinico Umberto i di Roma, Rome
Azienda Ospedaliera S. Maria - Terni, Terni
Nagoya University Hospital, Aichi
Hirosaki University Hospital, Aomori
National Hospital Organization Shikoku Cancer Center, Ehime
Gunma University Hospital, Gunma
National Hospital Organization Hokkaido Cancer Center, Hokkaido
University of Tsukuba Hospital, Ibaraki
Kanazawa University Hospital, Ishikawa
Kumamoto University Hospital, Kumamoto
Niigata University Medical & Dental Hospital, Niigata
Osaka Metropolitan University Hospital, Osaka
Kindai University Hospital, Osaka
Toranomon Hospital, Tokyo
The Cancer Institute Hospital, JFCR, Tokyo
Keio University Hospital, Tokyo
Health Pharma Professional Research, CD Mexico
IMSS Hospital General de Zona No. 48 S. Pedro Xalpa, Mexico CITY (federal District)
Martini Ziekenhuis, Groningen
Hagaziekenhuis, locatie Leyweg, NL -DEN HAAG
Zuyderland Medisch Centrum, Sittard-Geleen
Isala Klinieken, Sophia, Zwolle
Bialostockie Centrum Onkologii, Bialystok
Przychodnia Lekarska KOMED, Roman Karaszewski, Konin
Szpital Uniwersytecki w Krakowie, Krakow
Woj.Wielospecjalistyczne Centrum Onkologii i Traumatologii, Lodz
Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu, Poznan
NU-MED Centrum Diagnostyki i Terapii Onkologicznej, Tomaszów Mazowiecki
Szpital Grochowski im. dr med. Rafa?a Masztaka Sp. z o.o., Warsaw
Hospital de Santa Maria, Lisbon
IPO do Porto, Porto
Institute Of Oncology Bucharest, Bucharest
Wilgers Oncology Centre, Pretoria
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Hospital General Universitario de Elche, Elche
Hospital Universitario Son Espases, Palma de Mallorca
Complejo Hospitalario de Althaia, Manresa
Corporacio Sanitaria Parc Tauli, Sabadell
Complejo Hospitalario Universitario de Albacete, Albacete
Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Barcelona
Hospital Clinic de Barcelona. Unidad de Nuevas Terapias, Barcelona
Hospital de la Santa Creu i Sant Pau, Barcelona
Institutio Catalan De Oncologia, Barcelona
Hospital Universitari Germans Trias i Pujol, Barcelona
Complejo Asistencial Universitario De Burgos, Burgos
Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital, Adana
Ankara Bilkent City Hospital, Ankara
Hacettepe Uni Medical Faculty Hospital, S?hhiye, Ankara
Beatson West of Scotland Cancer Centre, Glasgow
University College London Hospitals NHS Foundation Trust - University College Hospital, London
The Christie NHS Foundation Trust, Manchester
The York Hospital, York
Hoffmann-La Roche
INDUSTRY