Monotherapy With Rapamycin in Long-standing Type 1 Diabetes

Rapamycin will be administered at an initial dose 0.2 mg/kg on day 0, followed by 0.1 mg/kg/die. The daily dose will be adjusted to the whole blood 24-hr trough to target, as tolerated, 8-10 ng/mL

Vildagliptin will be administered at a dose of 50 mg x2/die starting from day 0.

Placebo 1 will be titrated according to a random schedule alternating plausible doses of placebo. After 4 weeks of treatment patients will discontinue placebo 1

Placebo 2 will be administered BID starting from day 0. After 8 weeks of treatment patients will discontinue placebo 2