Circulatory Management and Acute Kidney Injury in Patients Undergoing Partial Nephrectomy

NACompletedINTERVENTIONAL
Enrollment

144

Participants

Timeline

Start Date

May 31, 2016

Primary Completion Date

December 31, 2016

Study Completion Date

October 31, 2017

Conditions
Acute Kidney Injury
Interventions
OTHER

Goal-directed circulatory management

In addition to routine monitoring, invasive LiDCOrapid is used to monitor MAP, SVV and CI. Intraoperative circulatory management is performed according to the goal-directed principal, i.e., to maintain MAP \> 95 mmHg, SVV \< 6%, and CI 3.0-4.0 L/min/m2, started from renal artery clamping and maintained until the end of surgery. Crystalloid solution is firstly infused to maintain SVV at the target level, dobutamine and/or noradrenaline are then infused to maintain MAP and CI at the target levels.

OTHER

Routine circulatory management

Routine monitoring is performed, which include invasive blood pressure and urine output. Intraoperative circulatory management is performed according to routine practice, i.e., to maintain blood pressure within 20% from baseline level and urine output \> 0.5 ml/kg/h by infusing crystalloid solution and administering vasoactive drugs when considered necessary.

Trial Locations (1)

100034

Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing

All Listed Sponsors
lead

Peking University First Hospital

OTHER

NCT02803372 - Circulatory Management and Acute Kidney Injury in Patients Undergoing Partial Nephrectomy | Biotech Hunter | Biotech Hunter