NCT02801032 - Effect of Tadalafil on Cerebral Large Arteries in Stroke | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

November 29, 2016

Primary Completion Date

August 4, 2017

Study Completion Date

August 4, 2017

Conditions

Stroke, LacunarCerebral Small Vessel Diseases

Interventions

DRUG

Tadalafil

"Single dose, 20 mg capsule p.o. minimum one week apart from placebo.~MRI of cerebrum before the first trial day.~Transcranial Doppler to measure blood flow velocity in MCA bilaterally before and after intervention.~Near-infrared spectroscopy (NIRS) to measure cortical brain oxygenation before and after intervention.~EndoPAT2000 to estimate endothelial function before and after intervention.~Endothelial biomarkers in blood samples before and after intervention."

DRUG

Placebo

"Single dose, matching capsule p.o. minimum one week apart from active treatment.~MRI of cerebrum before the first trial day.~Transcranial Doppler to measure blood flow velocity in MCA bilaterally before and after intervention.~Near-infrared spectroscopy (NIRS) to measure cortical brain oxygenation before and after intervention.~EndoPAT2000 to estimate endothelial function before and after intervention.~Endothelial biomarkers in blood samples before and after intervention."

Trial Locations (1)

2730

Department of Neurology, Herlev-Gentofte Hospital, Herlev

All Listed Sponsors

lead

Christina Kruuse

OTHER