1,552
Participants
Start Date
May 31, 2016
Primary Completion Date
March 5, 2020
Study Completion Date
September 1, 2021
Cefoxitin, Ertapenem, Moxifloxacin, Tigecycline, Ticarcillin-Clavulanic Acid; Metronidazole plus Cefazolin, Cefuroxime, Ceftriaxone, Cefotaxime, Ciprofloxacin, or Levofloxacin
Patients will be offered a treatment regimen of antibiotics based on guidelines published jointly by the Surgical Infection Society and the Infectious Disease Society of America. After IV antibiotics are administered for a period of at least 24 hours, a regimen of oral antibiotics will be continued for a total treatment length of 10 days. Preferred oral antibiotic regimens include Moxifloxacin alone, and combinations such as Metronidazole or Clindamycin, for anaerobic bacteria coverage, plus Ciprofloxacin or Levofloxacin, or an oral Cephalosporin for aerobic Gram-negative bacteria coverage.
Appendectomy
Appendectomy will be performed by an open or laparoscopic approach, depending on patient and surgeon preference.
New York University - Bellevue Hospital, New York
New York University - Tisch Hospital, New York
Columbia University Medical Center, New York
Weill Cornell Medicine, New York
Vanderbilt University Medical Center, Nashville
University of Mississippi Medical Center, Jackson
The Ohio State University Medical Center, Columbus
Michigan Medicine- University of Michigan, Ann Arbor
Henry Ford Health System, Detroit
University of Iowa Hospitals and Clinics, Iowa City
Rush University Medical Center, Chicago
Lyndon B Johnson- Harris Health, Houston
The University of Texas Health Science Center at Houston, Houston
University of Colorado Denver, Aurora
Harbor-UCLA Medical Center, Torrance
Olive View-UCLA Medical Center, Sylmar
Harborview Medical Center, Seattle
Virginia Mason University Village Medical Center, Seattle
Swedish Medical Center- First Hill, Seattle
University of Washington Medical Center, Seattle
Providence Regional Medical Center Everett, Everett
Madigan Army Medical Center, Tacoma
Maine Medical Center, Portland
Boston Medical Center, Boston
Beth Israel Deaconess Medical Center, Boston
Patient-Centered Outcomes Research Institute
OTHER
University of Washington
OTHER