885
Participants
Start Date
September 25, 2017
Primary Completion Date
August 23, 2023
Study Completion Date
June 30, 2026
Degarelix
a GnRH antagonist will be given for a predefined duration of 18, 24, or 36 months as per institution policy
approved GnRH agonist
A non-steroidal anti-androgen (e. g. flutamide, bicalutamide) will be given orally one week before the first injection of the GnRH agonist and will be continued for no longer than 8 weeks to protect against flare.Dose may vary due to availability of different brand names and pharmaceutical forms The start of antiandrogen must be registered as day 1 of treatment in the GnRH agonist arm.
Radiotherapy
.As the study investigates the effect of two drugs given concomitantly to radiotherapy, all patients will be treated with the same treatment technique and target dose. The preferred treatment technique is intensity modulated radiotherapy (IMRT)
Hopitaux Universitaires Bordet-Erasme - Hopitaux Universitaires Bordet- Institut Jules Bordet, Brussels
Hopitaux Universitaires Bordet-Erasme - Hopital Universitaire Erasme, Brussels
Universitair Ziekenhuis Brussel, Brussels
Cliniques Universitaires Saint-Luc, Brussels
University Hospitals Copenhagen - Rigshospitalet, Copenhagen
Gasthuiszusters van Antwerpen - GasthuisZusters Antwerpen - Sint-Augustinus, Wilrijk
Inselspital, Bern
CHU Ucl Namur - Site Sainte-Elisabeth, Namur
Centre de radiotherapie Marie Curie, Arras
Oncology Institute of Southern Switzerland (IOSI) - Oncology Institute of Southern Switzerland - Ospedale Regionale Bellinzona e Valli, Bellinzona
Hopital De Jolimont, Haine-Saint-Paul
AZ Groeninge Kortrijk - Campus Kennedylaan, Kortrijk
Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin, Berlin
Hospital Universitario Reina Sofia, Córdoba
Fundacion Hospital Alcorcon, Alcorcón
Hospital General Universitario Santa Lucia, Cartagena
Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria
Centre Hospitalier Privé Saint-Grégoire, Saint-Grégoire
Complejo Hospitalario Universitario de Vigo -CHUVI - Hospital Alvaro Cunqueiro, Vigo
Hospital Universitario de Salamanca, Salamanca
CHU de Grenoble - La Tronche - Hôpital A. Michallon, Grenoble
Otto-Von-Guericke-Universitaet Magdeburg - Universitaetsklinik, Magdeburg
Institut de Cancerologie de l'Ouest (ICO) - Centre Rene Gauducheau, Nantes
AUSL Romagna - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola
Clinica IMQ Zorrotzaurre, Bilbao
Azienda Ospedaliero-Universitaria Careggi, Florence
Groupe Radiopole Artois - Centre de Radiotherapie Pierre Curie, Beuvry
Centre D'Onco. & Radioth. De Haute Energie Du Pays Basque, Bayonne
Centre Leon Berard, Lyon
Assistance Publique - Hopitaux de Paris - La Pitie Salpetriere, Paris
Universitaetsklinikum Freiburg, Freiburg im Breisgau
Clinique de l'Europe, Amiens
Clinique Pasteur-Toulouse-Atrium, Toulouse
Institut Catala d'Oncologia - ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia), Barcelona
Complejo Hospitalario A, Pamplona
Hôpitaux universitaires de Genève - HUG - site de Cluse-Roseraie, Geneva
Corporacio Sanitaria Parc Tauli, Sabadell
Hospital Consorci Sanitari De Terrassa, Terrassa
Nottingham University Hospitals NHS Trust - City Hospital, Nottingham
European Organisation for Research and Treatment of Cancer - EORTC
NETWORK